Literature DB >> 6152043

Somatostatin and vasoactive intestinal polypeptide in postmortem brains from patients with Alzheimer-type dementia.

H Arai, T Moroji, K Kosaka.   

Abstract

Somatostatin- and vasoactive intestinal polypeptide (VIP)-like immunoreactivities (SLI and VLI, respectively) were measured, by radioimmunoassay, in 21 regions of postmortem brains from 7 histologically verified cases of patients with Alzheimer-type dementia (ATD) and 10 histologically normal controls. SLI was significantly reduced in the orbital cortex, hippocampus and putamen of ATD brains. Significant reduction of VLI in the ATD brains was also found in the insular and angulate cortex, which have not previously been examined biochemically for peptides. These results suggest that involvement of not only somotostatin- but also VIP-containing neurons may not be ruled out in ATD brains.

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Year:  1984        PMID： 6152043     DOI： 10.1016/0304-3940(84)90353-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

1.  Activity-dependent neuroprotective protein (ADNP) expression in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease.

Authors:  Rafael Fernandez-Montesinos; Manuel Torres; David Baglietto-Vargas; Antonia Gutierrez; Illana Gozes; Javier Vitorica; David Pozo
Journal:  J Mol Neurosci       Date:  2009-10-21       Impact factor: 3.444

Review 2.  Alterations in neuropeptides in aging and disease. Pathophysiology and potential for clinical intervention.

Authors:  A Leake; I N Ferrier
Journal:  Drugs Aging       Date:  1993 Sep-Oct       Impact factor: 3.923

3.  Lack of effect of chronic carbamazepine on brain somatostatin in the rat.

Authors:  S R Weiss; T Nguyen; D R Rubinow; C J Helke; P K Narang; R M Post; D M Jacobowitz
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

4.  Neuroprotective strategy for Alzheimer disease: intranasal administration of a fatty neuropeptide.

Authors:  I Gozes; A Bardea; A Reshef; R Zamostiano; S Zhukovsky; S Rubinraut; M Fridkin; D E Brenneman
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205

5.  Vasoactive intestinal polypeptide immunoreactivity in the human cerebellum: qualitative and quantitative analyses.

Authors:  Vincenzo Benagiano; Paolo Flace; Loredana Lorusso; Anna Rizzi; Lorenzo Bosco; Raffaele Cagiano; Glauco Ambrosi
Journal:  J Anat       Date:  2009-06-22       Impact factor: 2.610

Review 6.  [Relations between specific neurochemical systems and memory: problems posed by dementia of the Alzheimer type].

Authors:  I Lussier; E Stip
Journal:  J Psychiatry Neurosci       Date:  1995-01       Impact factor: 6.186

7.  VIP enhances phagocytosis of fibrillar beta-amyloid by microglia and attenuates amyloid deposition in the brain of APP/PS1 mice.

Authors:  Min Song; Jia-xiang Xiong; Yan-yan Wang; Jun Tang; Bo Zhang; Yun Bai
Journal:  PLoS One       Date:  2012-02-06       Impact factor: 3.240
  7 in total

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