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Literature DB >> 2881977

Lack of effect of chronic carbamazepine on brain somatostatin in the rat.

S R Weiss, T Nguyen, D R Rubinow, C J Helke, P K Narang, R M Post, D M Jacobowitz.

Abstract

We investigated the effects of chronic carbamazepine treatment in rats on brain somatostatin. Following 12 days of carbamazepine treatment, no changes in somatostatin levels were found in any of the brain areas examined which included: amygdala, hippocampus, caudate-putamen, median eminence, arcuate nucleus, nucleus accumbens, nucleus interstitialis of the stria terminalis, nucleus periventricularis, parietal cortex, and occipital cortex. Thus, carbamazepine in low doses does not affect basal levels of brain somatostatin in the rat, in contrast to the previous reports of decreased somatostatin in the cerebrospinal fluid of affectively ill patients.

Entities: Chemical Gene Species

Mesh：

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Year: 1987 PMID： 2881977 DOI： 10.1007/bf02098507

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

34 in total

1. Carbamazepine: biotransformation.

Authors: A Frigerio; P L Morselli
Journal: Adv Neurol Date: 1975

2. Prophylactic efficacy of carbamazepine in manic-depressive illness.

Authors: R M Post; T W Uhde; J C Ballenger; K M Squillace
Journal: Am J Psychiatry Date: 1983-12 Impact factor: 18.112

3. Regional brain concentrations of neuropeptides in Huntington's chorea and schizophrenia.

Authors: C B Nemeroff; W W Youngblood; P J Manberg; A J Prange; J S Kizer
Journal: Science Date: 1983-09-02 Impact factor: 47.728

4. Cerebrospinal fluid somatostatin and psychiatric illness.

Authors: D R Rubinow
Journal: Biol Psychiatry Date: 1986-04 Impact factor: 13.382

5. Somatostatin is increased in the nucleus accumbens in Huntington's disease.

Authors: M F Beal; E D Bird; P J Langlais; J B Martin
Journal: Neurology Date: 1984-05 Impact factor: 9.910

6. Low levels of somatostatin in human CSF mark depressive episodes.

Authors: H Agren; G Lundqvist
Journal: Psychoneuroendocrinology Date: 1984 Impact factor: 4.905

7. Development of a new pharmacological seizure model: effects of anticonvulsants on cortical- and amygdala-kindled seizures in the rat.

Authors: P S Albright; W M Burnham
Journal: Epilepsia Date: 1980-12 Impact factor: 5.864

Lack of effect of chronic carbamazepine on brain somatostatin in the rat.

1. Carbamazepine: biotransformation.

2. Prophylactic efficacy of carbamazepine in manic-depressive illness.

3. Regional brain concentrations of neuropeptides in Huntington's chorea and schizophrenia.

4. Cerebrospinal fluid somatostatin and psychiatric illness.

5. Somatostatin is increased in the nucleus accumbens in Huntington's disease.

6. Low levels of somatostatin in human CSF mark depressive episodes.

7. Development of a new pharmacological seizure model: effects of anticonvulsants on cortical- and amygdala-kindled seizures in the rat.

8. A pharmacological study in the kindling model of epilepsy.

9. Chronic carbamazepine treatment increases brain adenosine receptors.

10. A double-blind study comparing carbamazepine with phenytoin as initial seizure therapy in adults.

Review 1. Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?