| Literature DB >> 6147640 |
J P Neijt, W W ten Bokkel Huinink, M E van der Burg, A T van Oosterom, R Vriesendorp, C D Kooyman, A C van Lindert, J V Hamerlynck, M van Lent, J C van Houwelingen.
Abstract
186 patients with advanced epithelial ovarian carcinoma were treated with either a combination of hexamethylmelamine, cyclophosphamide, methotrexate, and 5-fluorouracil (Hexa-CAF) or cyclophosphamide and hexamethylmelamine alternating with doxorubicin and a 5-day course of cisplatin (CHAP-5). Treatment with CHAP-5 resulted in more complete remissions as determined by laparatomy or peritoneoscopy (p = 0.004), better overall response (p = 0.0001), and longer overall survival and progression-free survival (p less than 0.002). Therapy, histological grade, and Karnofsky index were reliable predictors of overall response, whereas therapy, FIGO-stage, and size of residual tumour before chemotherapy were independent predictors for complete remission and for prolonged survival. Peripheral neurotoxicity was a major problem in patients assigned to the CHAP-5-group and was likely to be due to the simultaneous administration of hexamethylmelamine and cisplatin. The CHAP-5 regimen is one of the most effective regimens for the initial treatment of ovarian cancer.Entities:
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Year: 1984 PMID： 6147640 DOI： 10.1016/s0140-6736(84)90594-4
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321