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Literature DB >> 6147393

Effect of neuroleptic treatment on involuntary movements and motor performances in Huntington's disease.

F Girotti, F Carella, G Scigliano, M P Grassi, P Soliveri, P Giovannini, E Parati, T Caraceni.

Abstract

Eighteen patients with Huntington's chorea were examined before and after neuroleptic treatment (haloperidol, pimozide, tiapride) to study the effect of such treatment on hyperkinesia and motor performance. Pimozide and haloperidol improved hyperkinesia; none of the drugs significantly affected motor performance. No correlation was found between the severity of hyperkinesia and motor performance scores, or between hyperkinesia and intelligence score, before and after therapy.

Entities: Chemical Disease Species

Mesh：

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Year: 1984 PMID： 6147393 PMCID： PMC1027950 DOI： 10.1136/jnnp.47.8.848

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

10 in total

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Authors: P E Roland; B Larsen; N A Lassen; E Skinhøj
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Authors: T Caraceni; G Calderini; A Consolazione; E Riva; S Algeri; F Girotti; R Spreafico; A Branciforti; A Dall'olio; P L Morselli
Journal: J Neurol Neurosurg Psychiatry Date: 1977-06 Impact factor: 10.154

10 in total

17 in total

Effect of neuroleptic treatment on involuntary movements and motor performances in Huntington's disease.

1. A brief psychogeriatric assessment schedule. Validation against psychiatric diagnosis and discharge from hospital.

2. Pharmacology of Huntington's chorea. Personal experience.

3. Comparative neuropsychological study of the changes in different programmed activities in subjects with frontal or retro-rolandic lesions or with Huntington's chorea.

4. Simple and complex finger movement performance of patients with Parkinsonism before and after a unilateral stereotaxic thalamotomy.

5. Huntington disease: functional capacities in patients treated with neuroleptic and antidepressant drugs.

6. The mysterious motor function of the basal ganglia: the Robert Wartenberg Lecture.

7. Patterns of neuropsychological test performance in Huntington's disease.

8. Basal ganglia disease.

9. Supplementary motor area and other cortical areas in organization of voluntary movements in man.

10. Biochemical aspects of Huntington's chorea.

1. Clozapine versus placebo in Huntington's disease: a double blind randomised comparative study.

Review 2. Do neuroleptic drugs still have a place in neurological therapy?

Review 3. Huntington's disease: the coming of age.

4. Treatment of huntington disease.

5. Tiapride in 12 Huntington's disease patients.

6. The relationship between impairment of voluntary movements and cognitive impairment in Huntington's disease.

7. Small molecule regulators of autophagy identified by an image-based high-throughput screen.

Review 8. An Update on the Treatment of Chorea.

9. Relationship between motor and cognitive disorders in Huntington's disease.

10. State-of-the-art pharmacological approaches to reduce chorea in Huntington's disease.