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Literature DB >> 2974882

Relationship between motor and cognitive disorders in Huntington's disease.

F Girotti¹, R Marano, P Soliveri, G Geminiani, G Scigliano.

Abstract

Akinesia and mental decline appear to be more appropriate criteria than hyperkinesia for the evaluation of the stage and progression of Huntington's disease (HD). In order to establish the relationship between motor and cognitive impairment in the disease, 20 non-demented HD patients were compared with 44 control subjects with respect to motor and cognitive performance. HD patients were significantly impaired in almost all cognitive functions in comparison with controls. Reaction time (RT) and movement time (MT) were considerably slower in HD patients when compared with controls and with patients with parkinsonism. Hyperkinesias did not correlate with cognitive impairment, but there was a good correlation between RT, MT and cognitive functions. Therefore, it seems that akinesia evaluated by RT and MT is an important sign in HD and proceeds at the same rate as mental decay.

Entities: Disease Species

Mesh：

Year: 1988 PMID： 2974882 DOI： 10.1007/bf00314246

Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849

16 in total

7. Functional and cognitive capacity differ in dystonic motor subtypes when compared to choreatic and hypokinetic-rigid motor subtypes in Huntington's disease.

Authors: Jannis Achenbach; Sarah Maria von Hein; Carsten Saft
Journal: Brain Behav Date: 2020-06-12 Impact factor: 2.708

7 in total

Relationship between motor and cognitive disorders in Huntington's disease.

1. Rigid and akinetic forms of Huntington's chorea.

2. Comparison of the neuropsychological deficits associated with early and advanced Huntington's disease.

3. Reaction time in Parkinson's disease.

4. Classification of extrapyramidal disorders. Proposal for an international classification and glossary of terms.

5. Visuospatial judgment. A clinical test.

6. The measurement of abnormal movement: methods developed for Huntington's disease.

7. Dementia in Huntington disease: a cross-sectional analysis of intellectual decline.

8. Development of neuropsychological deficits in Huntington's disease.

9. Impairment of rapid movement in Huntington's disease.

10. Correlates of early disability in Huntington's disease.

1. Movement sequencing in Huntington disease.

2. Sensorimotor mapping affects movement correction deficits in early Huntington's disease.

3. The relationship between impairment of voluntary movements and cognitive impairment in Huntington's disease.

4. A comparative study of simple and choice reaction time in Parkinson's, Huntington's and cerebellar disease.

Review 5. Huntington's disease: pathogenesis, diagnosis and treatment.

6. Progression of motor subtypes in Huntington's disease: a 6-year follow-up study.

7. Functional and cognitive capacity differ in dystonic motor subtypes when compared to choreatic and hypokinetic-rigid motor subtypes in Huntington's disease.