Literature DB >> 6146685

Preparation and evaluation of biodegradable polymeric systems for the intra-articular delivery of drugs.

J H Ratcliffe, I M Hunneyball, A Smith, C G Wilson, S S Davis.   

Abstract

Colloidal suspensions of four biodegradable polymers, polylactic acid (PLA), polybutylcyanoacrylate (PBCA), gelatin (PG) and albumin (PA) were prepared within the size range 1-10 micron. In-vivo biocompatibility tests with synovial tissues were carried out to assess the irritancy of the polymers following intra-articular injection into rabbit knee joints. PLA, PBCA and PG were found to cause joint inflammation whereas PA was well tolerated by the tissues. PA microspheres may provide a means of sustaining the release and reducing the rate of clearance of drugs from the knee joint.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6146685     DOI： 10.1111/j.2042-7158.1984.tb04419.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  17 in total

1.  Improved activity of a new angiotensin receptor antagonist by an injectable spray-dried polymer microsphere preparation.

Authors:  F X Lacasse; P Hildgen; J Pérodin; E Escher; N C Phillips; J N McMullen
Journal:  Pharm Res       Date:  1997-07       Impact factor: 4.200

2.  Silylated precision particles for controlled release of proteins.

Authors:  Khosrow Khodabandehlou; Amar S Kumbhar; Sohrab Habibi; Ashish A Pandya; J Christopher Luft; Saad A Khan; Joseph M DeSimone
Journal:  ACS Appl Mater Interfaces       Date:  2015-03-05       Impact factor: 9.229

3.  Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbit.

Authors:  Eijiro Horisawa; Tsuyoshi Hirota; Satoko Kawazoe; Jun Yamada; Hiromitsu Yamamoto; Hirofumi Takeuchi; Yoshiaki Kawashima
Journal:  Pharm Res       Date:  2002-04       Impact factor: 4.200

4.  Erosion kinetics of hydrolytically degradable polymers.

Authors:  J A Tamada; R Langer
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

5.  Influence of surface properties at biodegradable microsphere surfaces: effects on plasma protein adsorption and phagocytosis.

Authors:  F X Lacasse; M C Filion; N C Phillips; E Escher; J N McMullen; P Hildgen
Journal:  Pharm Res       Date:  1998-02       Impact factor: 4.200

6.  Hydrolytic Degradation and Erosion of Polyester Biomaterials.

Authors:  Lindsay N Woodard; Melissa A Grunlan
Journal:  ACS Macro Lett       Date:  2018-07-30       Impact factor: 6.903

7.  Formulation and optimization of nonionic surfactants emulsified nimesulide-loaded PLGA-based nanoparticles by design of experiments.

Authors:  Ceyda Tuba Sengel Turk; Umut Can Oz; Tugrul Mert Serim; Canan Hascicek
Journal:  AAPS PharmSciTech       Date:  2013-11-13       Impact factor: 3.246

8.  Particles for Local Delivery of Proteins Using Intra-Articular Route.

Authors:  Khosrow Khodabandehlou; Shaomin Tian; James C Luft; Saad A Khan; Joseph M DeSimone
Journal:  Adv Healthc Mater       Date:  2016-02-02       Impact factor: 9.933

9.  Design of methylprednisolone biodegradable microspheres intended for intra-articular administration.

Authors:  Francesco Cilurzo; Francesca Selmin; Paola Minghetti; Luisa Montanari
Journal:  AAPS PharmSciTech       Date:  2008-11-14       Impact factor: 3.246

Review 10.  Gelatin Methacrylate (GelMA)-Based Hydrogels for Cell Transplantation: an Effective Strategy for Tissue Engineering.

Authors:  Shining Xiao; Tengfei Zhao; Jingkai Wang; Chenggui Wang; Jiangnan Du; Liwei Ying; Jiangtao Lin; Caihua Zhang; Wanglu Hu; Linlin Wang; Kan Xu
Journal:  Stem Cell Rev Rep       Date:  2019-10       Impact factor: 5.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.