Literature DB >> 26833828

Particles for Local Delivery of Proteins Using Intra-Articular Route.

Khosrow Khodabandehlou1, Shaomin Tian2, James C Luft2,3, Saad A Khan1, Joseph M DeSimone1,2,3,4.   

Abstract

Designing a vehicle for local delivery of proteins using intra-articular route is an attractive option to minimize the adverse effects associated with systemic exposure and to maximize the efficacy. Slowly dissolving silylated microparticles are designed with specific size and shape that are capable of extending the retention time of a model protein (bovine serum albumin) in the murine knee joint. No cytotoxicity is observed for the reconstituted formulation when tested against synovial fibroblasts and RAW 264.7 macrophages.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  bovine serum albumin; intra-articular; joint retention; microparticles; silylation

Mesh：

Substances：

Year:  2016        PMID： 26833828      PMCID： PMC4852977          DOI： 10.1002/adhm.201500797

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  38 in total

1.  Shape-specific, monodisperse nano-molding of protein particles.

Authors:  Jennifer Y Kelly; Joseph M DeSimone
Journal:  J Am Chem Soc       Date:  2008-04-01       Impact factor: 15.419

2.  Albumin microspheres for intra-articular drug delivery: investigation of their retention in normal and arthritic knee joints of rabbits.

Authors:  J H Ratcliffe; I M Hunneyball; C G Wilson; A Smith; S S Davis
Journal:  J Pharm Pharmacol       Date:  1987-04       Impact factor: 3.765

3.  Silylated precision particles for controlled release of proteins.

Authors:  Khosrow Khodabandehlou; Amar S Kumbhar; Sohrab Habibi; Ashish A Pandya; J Christopher Luft; Saad A Khan; Joseph M DeSimone
Journal:  ACS Appl Mater Interfaces       Date:  2015-03-05       Impact factor: 9.229

Review 4.  Designing micro- and nano-particles for treating rheumatoid arthritis.

Authors:  Samir Mitragotri; Jin-Wook Yoo
Journal:  Arch Pharm Res       Date:  2011-12-03       Impact factor: 4.946

5.  Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis.

Authors:  Andreas Wunder; Ulf Müller-Ladner; Ernst H K Stelzer; Jürgen Funk; Elena Neumann; Gerd Stehle; Thomas Pap; Hannsjörg Sinn; Steffen Gay; Christoph Fiehn
Journal:  J Immunol       Date:  2003-05-01       Impact factor: 5.422

6.  Incorporation and controlled release of silyl ether prodrugs from PRINT nanoparticles.

Authors:  Matthew C Parrott; Mathew Finniss; J Chris Luft; Ashish Pandya; Anuradha Gullapalli; Mary E Napier; Joseph M DeSimone
Journal:  J Am Chem Soc       Date:  2012-04-30       Impact factor: 15.419

7.  Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits.

Authors:  R T Liggins; T Cruz; W Min; L Liang; W L Hunter; H M Burt
Journal:  Inflamm Res       Date:  2004-08-10       Impact factor: 4.575

8.  Gelatin/chondroitin 6-sulfate microspheres for the delivery of therapeutic proteins to the joint.

Authors:  K E Brown; K Leong; C H Huang; R Dalal; G D Green; H B Haimes; P A Jimenez; J Bathon
Journal:  Arthritis Rheum       Date:  1998-12

9.  Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice.

Authors:  W B van den Berg; L B van de Putte; W A Zwarts; L A Joosten
Journal:  J Clin Invest       Date:  1984-11       Impact factor: 14.808

10.  Synovial fibroblasts spread rheumatoid arthritis to unaffected joints.

Authors:  Stephanie Lefèvre; Anette Knedla; Christoph Tennie; Andreas Kampmann; Christina Wunrau; Robert Dinser; Adelheid Korb; Eva-Maria Schnäker; Ingo H Tarner; Paul D Robbins; Christopher H Evans; Henning Stürz; Jürgen Steinmeyer; Steffen Gay; Jürgen Schölmerich; Thomas Pap; Ulf Müller-Ladner; Elena Neumann
Journal:  Nat Med       Date:  2009-11-08       Impact factor: 53.440
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  1 in total

1.  Functional amyloid-chitin hybrid ink coupled with flexible fabrication approaches for diverse macro and micro-structures.

Authors:  Shicao Wei; Yingfeng Li; Ke Li; Anqi Kang; Siyu Zhang; Teng Feng; Hui Zhang; Chao Zhong
Journal:  Mater Today Bio       Date:  2021-12-02
  1 in total

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