Literature DB >> 6146362

Multidrug resistance.

V Ling, J Gerlach, N Kartner.   

Abstract

Mutations resulting in a complex phenotype of cross-resistance and collateral-sensitivity are frequently observed in mammalian cell lines. A cell surface 170 000 dalton glycoprotein (P-glycoprotein) has been identified to be intimately associated with this multidrug resistance phenotype. We speculate that such mutations also occur in advanced cancers and play a major role in contributing to the non-response to combination chemotherapy. In this context, P-glycoprotein may be a useful molecular marker for diagnostic and therapeutic applications.

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Year:  1984        PMID： 6146362     DOI： 10.1007/bf01806390

Source DB:  PubMed          Journal:  Breast Cancer Res Treat        ISSN： 0167-6806            Impact factor:   4.872


  19 in total

1.  Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

Authors:  W T Beck; T J Mueller; L R Tanzer
Journal:  Cancer Res       Date:  1979-06       Impact factor: 12.701

2.  Dominance of colchicine resistance in hybrid CHO cells.

Authors:  V Ling; R M Baker
Journal:  Somatic Cell Genet       Date:  1978-03

Review 3.  Vinca alkaloid-resistant phenotype in cultured human leukemic lymphoblasts.

Authors:  W T Beck
Journal:  Cancer Treat Rep       Date:  1983-10

Review 4.  Multidrug-resistance phenotype in Chinese hamster ovary cells.

Authors:  V Ling; N Kartner; T Sudo; L Siminovitch; J R Riordan
Journal:  Cancer Treat Rep       Date:  1983-10

Review 5.  Double minutes and homogeneously staining regions: gene amplification in mammalian cells.

Authors:  J K Cowell
Journal:  Annu Rev Genet       Date:  1982       Impact factor: 16.830

6.  Specific karyotypic alterations in colchicine-resistant cells.

Authors:  B P Kopnin
Journal:  Cytogenet Cell Genet       Date:  1981

7.  Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability.

Authors:  J R Riordan; V Ling
Journal:  J Biol Chem       Date:  1979-12-25       Impact factor: 5.157

8.  DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.

Authors:  P G Debenham; N Kartner; L Siminovitch; J R Riordan; V Ling
Journal:  Mol Cell Biol       Date:  1982-08       Impact factor: 4.272

9.  Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines.

Authors:  N Kartner; J R Riordan; V Ling
Journal:  Science       Date:  1983-09-23       Impact factor: 47.728

10.  Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells.

Authors:  F Baskin; R N Rosenberg; V Dev
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205
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  12 in total

1.  Predicting chemosensitivity of tumors.

Authors:  J Mattern; K Wayss; M Volm
Journal:  Breast Cancer Res Treat       Date:  1986       Impact factor: 4.872

2.  Saturable process involved in active efflux of vincristine as a mechanism of multidrug resistance in P388 leukemia cells.

Authors:  T Watanabe; M Inaba; Y Sugiyama
Journal:  Pharm Res       Date:  1989-08       Impact factor: 4.200

3.  Triptolide exerts pro-apoptotic and cell cycle arrest activity on drug-resistant human lung cancer A549/Taxol cells via modulation of MAPK and PI3K/Akt signaling pathways.

Authors:  Chen Qiong Xie; Ping Zhou; Jian Zuo; Xiang Li; Yong Chen; Jian Wei Chen
Journal:  Oncol Lett       Date:  2016-09-07       Impact factor: 2.967

4.  Selection of tumor cell variants for resistance to tumor necrosis factor also induces a form of pleiotropic drug resistance.

Authors:  S C Wright; A W Tam; P Kumar
Journal:  Cancer Immunol Immunother       Date:  1992       Impact factor: 6.968

5.  Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells.

Authors:  J Shen; C Hughes; C Chao; J Cai; C Bartels; T Gessner; J Subjeck
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

Review 6.  Quantitative genetic analysis of tumor progression.

Authors:  V Ling; A F Chambers; J F Harris; R P Hill
Journal:  Cancer Metastasis Rev       Date:  1985       Impact factor: 9.264

7.  Drug resistance as a dynamic process in a model for multistep gene amplification under various levels of selection stringency.

Authors:  L E Harnevo; Z Agur
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

8.  A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain.

Authors:  A M Van der Bliek; M B Meyers; J L Biedler; E Hes; P Borst
Journal:  EMBO J       Date:  1986-12-01       Impact factor: 11.598

9.  Solution structure of a purine rich hexaloop hairpin belonging to PGY/MDR1 mRNA and targeted by antisense oligonucleotides.

Authors:  Flore Joli; Nadia Bouchemal; Alain Laigle; Brigitte Hartmann; Edith Hantz
Journal:  Nucleic Acids Res       Date:  2006-10-13       Impact factor: 16.971

10.  Flow cytometric analysis of Hoechst 33342 uptake as an indicator of multi-drug resistance in human lung cancer.

Authors:  S A Morgan; J V Watson; P R Twentyman; P J Smith
Journal:  Br J Cancer       Date:  1989-09       Impact factor: 7.640
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