| Literature DB >> 6144564 |
A McRae-Degueurce, C M Sinton.
Abstract
Variations in tyrosine hydroxylase (TH) activity and serotonin (5-HT) content in the rat locus coeruleus were measured four days after lesion of the nucleus raphe centralis superior. Lesions were made under either ether or pentobarbital anaesthesia and, in addition, (under ether) in rats pretreated with atropine or with lesions of the medial septum. Results showed a dissociation between 5-HT reduction and TH induction, differences due to the anaesthetic used, and a possible influence from limbic centres on 5-HT in the LC. These findings are discussed in terms of the apparent complexity of raphe-coerulean interactions.Entities:
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Year: 1984 PMID: 6144564 DOI: 10.1007/bf00236239
Source DB: PubMed Journal: Exp Brain Res ISSN: 0014-4819 Impact factor: 1.972