Literature DB >> 6144109

Self-administration of central stimulants by rats: a comparison of the effects of d-amphetamine, methylphenidate and McNeil 4612.

J A Nielsen, N J Duda, D J Mokler, K E Moore.   

Abstract

Rats were trained to press a lever for the intravenous administration of d-amphetamine. The rate of responding was decreased in a dose-dependent and time-related manner by non-contingent injections of d-amphetamine, methylphenidate or McNeil 4612. Methylphenidate and McNeil 4612 also maintained self-administration behavior when they were substituted for d-amphetamine, whereas substitution of saline for d-amphetamine resulted in extinction of the self-administration behavior. These data suggest that methylphenidate and McNeil 4612, like d-amphetamine, can act as reinforcers in rats.

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Year:  1984        PMID： 6144109     DOI： 10.1016/0091-3057(84)90247-8

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  10 in total

1.  Oral methylphenidate establishes a conditioned place preference in rats.

Authors:  Thomas E Wooters; Matthew T Walton; Michael T Bardo
Journal:  Neurosci Lett       Date:  2010-10-23       Impact factor: 3.046

2.  Strain differences in self-administration of methylphenidate and sucrose pellets in a rat model of attention-deficit hyperactivity disorder.

Authors:  Julie A Marusich; William Travis McCuddy; Joshua S Beckmann; Cassandra D Gipson; Michael T Bardo
Journal:  Behav Pharmacol       Date:  2011-12       Impact factor: 2.293

3.  Traumatic brain injuries during development disrupt dopaminergic signaling.

Authors:  Kate Karelina; Kristopher R Gaier; Zachary M Weil
Journal:  Exp Neurol       Date:  2017-08-09       Impact factor: 5.330

4.  Methylphenidate as a reinforcer for rats: contingent delivery and intake escalation.

Authors:  Julie A Marusich; Joshua S Beckmann; Cassandra D Gipson; Michael T Bardo
Journal:  Exp Clin Psychopharmacol       Date:  2010-06       Impact factor: 3.157

5.  The effects of adolescent methylphenidate self-administration on responding for a conditioned reward, amphetamine-induced locomotor activity, and neuronal activation.

Authors:  Christie L Burton; José N Nobrega; Paul J Fletcher
Journal:  Psychopharmacology (Berl)       Date:  2009-12-18       Impact factor: 4.530

6.  High impulsivity in rats predicts amphetamine conditioned place preference.

Authors:  Justin R Yates; Julie A Marusich; Cassandra D Gipson; Joshua S Beckmann; Michael T Bardo
Journal:  Pharmacol Biochem Behav       Date:  2011-07-23       Impact factor: 3.533

7.  The interactive effects of methylphenidate and ethanol on ethanol consumption and locomotor activity in mice.

Authors:  William C Griffin; Andrew J Novak; Lawrence D Middaugh; Kennerly S Patrick
Journal:  Pharmacol Biochem Behav       Date:  2010-02-01       Impact factor: 3.533

8.  Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors.

Authors:  P K Thanos; C Bermeo; M Rubinstein; K L Suchland; G J Wang; D K Grandy; N D Volkow
Journal:  J Psychopharmacol       Date:  2009-03-12       Impact factor: 4.153

9.  Differences in impulsivity on a delay-discounting task predict self-administration of a low unit dose of methylphenidate in rats.

Authors:  Julie A Marusich; Michael T Bardo
Journal:  Behav Pharmacol       Date:  2009-09       Impact factor: 2.293

10.  Characterization of methylphenidate self-administration and reinstatement in the rat.

Authors:  Leigh C P Botly; Christie L Burton; Zoë Rizos; Paul J Fletcher
Journal:  Psychopharmacology (Berl)       Date:  2008-05-16       Impact factor: 4.530
  10 in total

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