Literature DB >> 6143691

The human carcinoma cell line A431 possesses large numbers of functional beta-adrenergic receptors.

C Delavier-Klutchko, J Hoebeke, A D Strosberg.   

Abstract

The existence of beta-adrenergic receptors was demonstrated on whole A431 cells as well as A431 membrane preparations by means of binding assays using the hydrophobic 1-[3H]dihydroalprenolol and the hydrophilic antagonist [3H]CGP-12,177 as beta-adrenergic ligands. Binding was stereospecific. The receptors, as shown by competition studies, proved to be of the beta 2-subtype and appeared functional in the stimulation of adenylate cyclase. The number of receptors per cell and the yield of receptor sites/mg membrane protein render the A431 cell a useful tool for the study of human beta-adrenergic receptors.

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Year:  1984        PMID： 6143691     DOI： 10.1016/0014-5793(84)80308-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  18 in total

1.  Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.

Authors:  L J Emorine; S Marullo; C Delavier-Klutchko; S V Kaveri; O Durieu-Trautmann; A D Strosberg
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

2.  Indirect immunofluorescence localization of beta-adrenergic receptors and G-proteins in human A431 cells.

Authors:  H Y Wang; M Berrios; C C Malbon
Journal:  Biochem J       Date:  1989-10-15       Impact factor: 3.857

3.  cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

Authors:  B K Kobilka; R A Dixon; T Frielle; H G Dohlman; M A Bolanowski; I S Sigal; T L Yang-Feng; U Francke; M G Caron; R J Lefkowitz
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

4.  The role of a low beta 1-adrenoceptor selectivity of [3H]CGP-12177 for resolving subtype-selectivity of competitive ligands.

Authors:  C Nanoff; M Freissmuth; W Schütz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-11       Impact factor: 3.000

5.  The beta 2-adrenergic receptors of human epidermoid carcinoma cells bear two different types of oligosaccharides which influence expression on the cell surface.

Authors:  P Cervantes-Olivier; C Delavier-Klutchko; O Durieu-Trautmann; S Kaveri; M Desmandril; A D Strosberg
Journal:  Biochem J       Date:  1988-02-15       Impact factor: 3.857

6.  beta-Adrenergic agonist activity of a monoclonal anti-idiotypic antibody.

Authors:  J G Guillet; S V Kaveri; O Durieu; C Delavier; J Hoebeke; A D Strosberg
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

7.  Comparison of three radioligands for the labelling of human beta-adrenoceptor subtypes.

Authors:  Nadja Niclauss; Martina B Michel-Reher; Astrid E Alewijnse; Martin C Michel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2006-10-07       Impact factor: 3.000

8.  Stereoselective hemodynamic effects of (R)-and (S)-propranolol in man.

Authors:  K Stoschitzky; W Lindner; M Rath; C Leitner; G Uray; G Zernig; T Moshammer; W Klein
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-04       Impact factor: 3.000

9.  Antigenic analysis of the second extra-cellular loop of the human beta-adrenergic receptors.

Authors:  Y Magnusson; S Höyer; R Lengagne; M P Chapot; J G Guillet; A Hjalmarson; A D Strosberg; J Hoebeke
Journal:  Clin Exp Immunol       Date:  1989-10       Impact factor: 4.330

10.  AKAR2-AKAP12 fusion protein "biosenses" dynamic phosphorylation and localization of a GPCR-based scaffold.

Authors:  Jiangchuan Tao; Hsien-Yu Wang; Craig C Malbon
Journal:  J Mol Signal       Date:  2010-04-22
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