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Literature DB >> 6143558

Stimulation of synaptosomal uptake of neurotransmitter amino acids by insulin: possible role of insulin as a neuromodulator.

D E Rhoads, R J DiRocco, L D Osburn, N A Peterson, E Raghupathy.

Abstract

Insulin stimulates in a dose-dependent manner (concentration range of 0.1 - 10 microM) the synaptosomal uptake of amino acids characterized by high-affinity, Na+-dependent, veratridine-sensitive transport systems. This stimulation is observed in synaptosomes prepared from each of several regions of the adult rat brain. Both the initial rate of amino acid uptake and the overall capacity for amino acid accumulation are increased. Since these transport systems have been associated with the neurotransmitter role of the amino acids, we postulate that insulin can modulate neurotransmission in the rat central nervous system by increasing the efficiency of neuroactive amino acid reuptake.

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Year: 1984 PMID： 6143558 DOI： 10.1016/0006-291x(84)90903-3

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

11 in total

1. Insulin effect on GABA uptake in astroglial primary cultures.

Authors: K Bouhaddi; P Thomopoulos; C Fages; M Khelil; M Tardy
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2. The effect of residual beta cell activity on menstruation and the reproductive hormone profile of insulin-dependent diabetics.

Authors: G M Prelević; M I Würzburger; L A Perić
Journal: Arch Gynecol Obstet Date: 1989 Impact factor: 2.344

3. Insulin receptor of human cerebral gliomas. Structure and function.

Authors: G Grunberger; W L Lowe; A McElduff; R P Glick
Journal: J Clin Invest Date: 1986-03 Impact factor: 14.808

4. Hypothalamic and cortical neurons of normotensive and spontaneously hypertensive rats are differently affected by streptozotocin diabetes.

Authors: V Affolter; P Boujon; G Bestetti; G L Rossi
Journal: Acta Neuropathol Date: 1986 Impact factor: 17.088

10. Insulin, insulin-like growth factor-1, insulin receptor, and insulin-like growth factor-1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus.

Authors: Alexandra Marcha Penha; Frank Schaeffel; Marita Feldkaemper
Journal: Mol Vis Date: 2011-05-31 Impact factor: 2.367

Stimulation of synaptosomal uptake of neurotransmitter amino acids by insulin: possible role of insulin as a neuromodulator.

1. Insulin effect on GABA uptake in astroglial primary cultures.

2. The effect of residual beta cell activity on menstruation and the reproductive hormone profile of insulin-dependent diabetics.

3. Insulin receptor of human cerebral gliomas. Structure and function.

4. Hypothalamic and cortical neurons of normotensive and spontaneously hypertensive rats are differently affected by streptozotocin diabetes.

5. Dexamethasone Alters the Appetite Regulation via Induction of Hypothalamic Insulin Resistance in Rat Brain.

6. Effect of starvation or streptozotocin-diabetes on phosphate-activated glutaminase of different rat brain regions.

7. Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease.

8. In vivo electrophysiological effects of insulin in the rat brain.

Review 9. Insulin in the brain: sources, localization and functions.

10. Insulin, insulin-like growth factor-1, insulin receptor, and insulin-like growth factor-1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus.