Literature DB >> 1538831

Effect of starvation or streptozotocin-diabetes on phosphate-activated glutaminase of different rat brain regions.

V Lellos1, M Moraitou, V Tselentis, H Philippidis, G Palaiologos.   

Abstract

Phosphate-activated glutaminase (PAG) was assayed in homogenates of brain cerebellum, hippocampus or striatum from normal, starved for 48 h to 120 h or streptozotocin-diabetic rats. Only the hippocampal enzyme was increased (47%) by diabetes. Starvation had no effect in any of the regions studied. PAG of synaptosomes or of non-synaptosomal mitochondria from the hippocampus was also increased by 48% and 22% respectively in diabetes. PAG of synaptosomes from the cortex, the cerebellum, or the striatum or of the non-synaptosomal mitochondria from the cortex were not affected by diabetes or prolonged (120 h) starvation. A suggestion is presented that peripheral insulin, indirectly, may regulate PAG activity in a specific region of the rat brain.

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Year:  1992        PMID： 1538831     DOI： 10.1007/bf00966791

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  25 in total

1.  Sequential amino acid measurements during experimental diabetic ketoacidosis.

Authors:  P J Blackshear
Journal:  Am J Physiol       Date:  1975-01

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Authors:  M K JOHNSON
Journal:  Biochem J       Date:  1960-12       Impact factor: 3.857

3.  Stimulation of synaptosomal uptake of neurotransmitter amino acids by insulin: possible role of insulin as a neuromodulator.

Authors:  D E Rhoads; R J DiRocco; L D Osburn; N A Peterson; E Raghupathy
Journal:  Biochem Biophys Res Commun       Date:  1984-03-30       Impact factor: 3.575

4.  Glutamine--a major substrate for nerve endings.

Authors:  H F Bradford; H K Ward; A J Thomas
Journal:  J Neurochem       Date:  1978-06       Impact factor: 5.372

5.  Modulation of high affinity GABA uptake into hippocampal synaptosomes by glucocorticoids.

Authors:  A L Miller; C Chaptal; B S McEwen; E J Peck
Journal:  Psychoneuroendocrinology       Date:  1978-04       Impact factor: 4.905

6.  The distribution of soluble and membrane-bound forms of glutaminase in pig brain.

Authors:  G A Nimmo; K F Tipton
Journal:  J Neurochem       Date:  1979-11       Impact factor: 5.372

7.  Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes.

Authors:  B K Krueger; J Forn; P Greengard
Journal:  J Biol Chem       Date:  1977-04-25       Impact factor: 5.157

8.  Rapid preparation of synaptosomes from mammalian brain using nontoxic isoosmotic gradient material (Percoll).

Authors:  A Nagy; A V Delgado-Escueta
Journal:  J Neurochem       Date:  1984-10       Impact factor: 5.372

9.  The maximal activity of phosphate-dependent glutaminase and glutamine metabolism in the colon and the small intestine of streptozotocin-diabetic rats.

Authors:  M S Ardawi
Journal:  Diabetologia       Date:  1987-02       Impact factor: 10.122

10.  Effect of cortico-striate pathway lesion on the activities of enzymes involved in synthesis and metabolism of amino acid neurotransmitters in the striatum.

Authors:  M Sandberg; H K Ward; H F Bradford
Journal:  J Neurochem       Date:  1985-01       Impact factor: 5.372
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  1 in total

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Authors:  Andrzej Szutowicz; Hanna Bielarczyk; Marlena Zyśk; Aleksandra Dyś; Anna Ronowska; Sylwia Gul-Hinc; Joanna Klimaszewska-Łata
Journal:  Neurochem Res       Date:  2016-12-30       Impact factor: 3.996
  1 in total

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