| Literature DB >> 6143086 |
C I Phillips, K Green, S M Gore, P M Cullen, M Campbell.
Abstract
A peripheral corticosteroid blocker RU 486-6, instilled as a 1% suspension at random into one eye of 12 rabbits, produced a consistent fall in intraocular pressure as measured by a hand-held applanation tonometer, when compared with the fellow control eye. This or a similar drug may be applicable for treatment of human open-angle glaucoma, or ocular hypertension, by eliminating that part of ocular tension attributable to the effect on aqueous outflow of the normal and fluctuating level of tissue corticosteroids.Entities:
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Year: 1984 PMID： 6143086 DOI： 10.1016/s0140-6736(84)91279-0
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321