Literature DB >> 7795556

Corticosteroid receptor antagonists: a current perspective.

W Sutanto1, E R de Kloet.   

Abstract

This review aims to highlight a selection of antagonists for the mineralocorticoid and glucocorticoid receptors. Concepts of these receptor systems are described, as is the mechanism of action of these steroids in the brain and periphery. Examples of commonly available and newly synthesized antimineralocorticoids and antiglucocorticoids are given, together with their pharmacological profiles and, when appropriate, clinical and therapeutic applications.

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Year:  1995        PMID： 7795556     DOI： 10.1007/bf01875052

Source DB:  PubMed          Journal:  Pharm World Sci        ISSN： 0928-1231


  115 in total

1.  Blocking the renal electrolyte effects of mineralocorticoids with an orally active steroidal spirolactone.

Authors:  C M KAGAWA
Journal:  Endocrinology       Date:  1960-07       Impact factor: 4.736

2.  Glucocorticoids and mineralocorticoids: antifibrotic and profibrotic components of wound healing.

Authors:  K T Weber
Journal:  J Lab Clin Med       Date:  1992-07

3.  Selective deletions in the 90 kDa heat shock protein (hsp90) impede hetero-oligomeric complex formation with the glucocorticosteroid receptor (GR) or hormone binding by GR.

Authors:  F Cadepond; N Jibard; N Binart; G Schweizer-Groyer; I Segard-Maurel; E E Baulieu
Journal:  J Steroid Biochem Mol Biol       Date:  1994-03       Impact factor: 4.292

4.  Aldosterone antagonists. 3. Synthesis and activities of steroidal 7 alpha-(alkoxycarbonyl)-15,16-methylene spirolactones.

Authors:  K Nickisch; D Bittler; H Laurent; W Losert; Y Nishino; E Schillinger; R Wiechert
Journal:  J Med Chem       Date:  1990-02       Impact factor: 7.446

5.  Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone.

Authors:  E P Gomez-Sanchez; C E Gomez-Sanchez
Journal:  Am J Physiol       Date:  1992-12

6.  Spironolactone and endocrine dysfunction.

Authors: 
Journal:  Ann Intern Med       Date:  1976-11       Impact factor: 25.391

7.  Mechanism of dexamethasone 21-mesylate antiglucocorticoid action: I. Receptor-antiglucocorticoid complexes do not competitively inhibit receptor-glucocorticoid complex activation of gene transcription in vivo.

Authors:  F D Sistare; G L Hager; S S Simons
Journal:  Mol Endocrinol       Date:  1987-09

8.  Absence of progestational activity of oral spironolactone.

Authors:  S T Nakajima; J R Brumsted; D H Riddick; M Gibson
Journal:  Fertil Steril       Date:  1989-07       Impact factor: 7.329

9.  Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action.

Authors:  C B Whorwood; M C Sheppard; P M Stewart
Journal:  Endocrinology       Date:  1993-06       Impact factor: 4.736

10.  Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro.

Authors:  M de Gasparo; U Joss; H P Ramjoué; S E Whitebread; H Haenni; L Schenkel; C Kraehenbuehl; M Biollaz; J Grob; J Schmidlin
Journal:  J Pharmacol Exp Ther       Date:  1987-02       Impact factor: 4.030
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  1 in total

1.  Facilitation of ethanol consumption by intracerebroventricular infusions of corticosterone.

Authors:  C Fahlke; E Hård; S Hansen
Journal:  Psychopharmacology (Berl)       Date:  1996-09       Impact factor: 4.530
  1 in total

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