Literature DB >> 6142995

Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.

R G Palmer, C J Doré, A M Denman.   

Abstract

Sister chromatid exchanges (SCEs), a sensitive measure of chromosome damage, were counted in peripheral-blood lymphocytes from 10 patients with Behcet's syndrome receiving chlorambucil. All patients had abnormal counts. Damage was related to both daily dose and duration of therapy and was occurring at a greater rate than its repair. The patient who had been treated the longest and had received the highest total dose also had the highest SCE count. He died from acute leukaemia. SCE analysis may provide a method for detecting patients at risk from oncogenic effects of cytotoxic drugs.

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Year:  1984        PMID： 6142995     DOI： 10.1016/s0140-6736(84)90125-9

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  11 in total

Review 1.  Herpes simplex virus and the rheumatic diseases.

Authors:  A M Denman; B K Pelton; W Hylton; R G Palmer; R Topper
Journal:  Rheumatol Int       Date:  1989       Impact factor: 2.631

2.  Sister chromatid exchange frequencies in patients with scleroderma and their relatives.

Authors:  R G Palmer; R S Pereira; C J Dore; A M Denman
Journal:  Ann Rheum Dis       Date:  1986-05       Impact factor: 19.103

Review 3.  The treatment of minimal change nephrotic syndrome: lessons learned from multicentre co-operative studies.

Authors:  J Brodehl
Journal:  Eur J Pediatr       Date:  1991-04       Impact factor: 3.183

4.  Sister chromatid exchange analysis in monitoring chlorambucil therapy in primary nephrotic syndrome of childhood.

Authors:  A Y Elzouki; K al-Nassar; M al-Ali; G Malik; F Elsharie; O P Jaiswal
Journal:  Pediatr Nephrol       Date:  1991-01       Impact factor: 3.714

5.  Moesin is a biomarker for the assessment of genotoxic carcinogens in mouse lymphoma.

Authors:  Yoen Jung Lee; In-Kwon Choi; Yhun Yhong Sheen; Sue Nie Park; Ho Jeong Kwon
Journal:  Mol Cells       Date:  2012-01-26       Impact factor: 5.034

6.  Twenty cases of sympathetic ophthalmia.

Authors:  T Jennings; H H Tessler
Journal:  Br J Ophthalmol       Date:  1989-02       Impact factor: 4.638

7.  Sensitivity of lymphocytes from patients with systemic lupus erythematosus to the induction of sister chromatid exchanges by alkylating agents and bromodeoxyuridine.

Authors:  R G Palmer; C A Smith-Burchnell; C J Doré; A M Denman
Journal:  Ann Rheum Dis       Date:  1987-02       Impact factor: 19.103

Review 8.  Clinical pharmacology and modification of autoimmunity and inflammation in rheumatoid disease.

Authors:  R Luqmani; C Gordon; P Bacon
Journal:  Drugs       Date:  1994-02       Impact factor: 9.546

9.  Chlorambucil induced chromosome damage in juvenile chronic arthritis.

Authors:  R G Palmer; S Varonos; C J Doré; A M Denman; B M Ansell
Journal:  Arch Dis Child       Date:  1985-11       Impact factor: 3.791

10.  Long-term effects of chemotherapy on lymphocyte chromosomes from patients treated for gestational trophoblastic tumours.

Authors:  B R Reeves; S D Lawler; G Casey; H Harris
Journal:  Br J Cancer       Date:  1985-11       Impact factor: 7.640
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