Literature DB >> 2998425

Long-term effects of chemotherapy on lymphocyte chromosomes from patients treated for gestational trophoblastic tumours.

B R Reeves, S D Lawler, G Casey, H Harris.   

Abstract

A cytogenetic follow-up study of patients treated with chemotherapy for gestational trophoblastic tumours was undertaken. In some cases, high levels of chromosome damage were found to persist in lymphocytes for several years after completion of therapy. These results are compared with those found in similar studies of non-malignant and other malignant diseases. The relevance of these findings to the risk of subsequent chemotherapy-induced malignancy is discussed.

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Year:  1985        PMID: 2998425      PMCID: PMC1977236          DOI: 10.1038/bjc.1985.249

Source DB:  PubMed          Journal:  Br J Cancer        ISSN: 0007-0920            Impact factor:   7.640


  11 in total

1.  Second neoplasm--a complication of cancer chemotherapy.

Authors:  B A Chabner
Journal:  N Engl J Med       Date:  1977-07-28       Impact factor: 91.245

2.  New Giemsa method for the differential staining of sister chromatids.

Authors:  P Perry; S Wolff
Journal:  Nature       Date:  1974-09-13       Impact factor: 49.962

3.  An improved banding technique exemplified in the karyotype analysis of two strains of rat.

Authors:  P H Gallimore; C R Richardson
Journal:  Chromosoma       Date:  1973       Impact factor: 4.316

Review 4.  Treatment of high-risk choriocarcinoma.

Authors:  K D Bagshawe
Journal:  J Reprod Med       Date:  1984-11       Impact factor: 0.142

Review 5.  Acute leukemia and immunosupressive drug use: a review of patients undergoing immunosuppressive therapy for non-neoplastic diseases.

Authors:  H W Grünwald; F Rosner
Journal:  Arch Intern Med       Date:  1979-04

6.  No increase in second tumors after cytotoxic chemotherapy for gestational trophoblastic tumors.

Authors:  G J Rustin; F Rustin; J Dent; M Booth; S Salt; K D Bagshawe
Journal:  N Engl J Med       Date:  1983-03-03       Impact factor: 91.245

7.  Difficulties in assessing the human health effect of mutagenic carcinogens by cytogenetic analyses.

Authors:  S Wolff
Journal:  Cytogenet Cell Genet       Date:  1982

8.  Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.

Authors:  R G Palmer; C J Doré; A M Denman
Journal:  Lancet       Date:  1984-02-04       Impact factor: 79.321

9.  Persistence of chromosome rearrangements in peripheral lymphocytes from patients treated with melphalan for ovarian carcinoma.

Authors:  B Lambert; K Holmberg; N Einhorn
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

10.  Risk and prognostic factors in trophoblastic neoplasia.

Authors:  K D Bagshawe
Journal:  Cancer       Date:  1976-09       Impact factor: 6.860

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