Literature DB >> 6140981

Profound suppression of kindled seizures by cysteamine: possible role of somatostatin to kindled seizures.

T Higuchi, G S Sikand, N Kato, J A Wada, H G Friesen.   

Abstract

Recently we reported significant increase in immunoreactive somatostatin content in various brain regions of amygdaloid-kindled rats. We report here that acute intraperitoneal administration of cysteamine, an agent reported to deplete brain and gastrointestinal immunoreactive somatostatin content in kindled rats, led to profound suppression of kindled seizures. Purified anti-somatostatin antibody injected intracerebroventricularly also blocked the kindled seizures. The results show that endogenous immunoreactive somatostatin has a role in the development of seizures in amygdaloid kindled rats.

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Year:  1983        PMID： 6140981     DOI： 10.1016/0006-8993(83)90118-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Highly specific neuron loss preserves lateral inhibitory circuits in the dentate gyrus of kainate-induced epileptic rats.

Authors:  P S Buckmaster; A L Jongen-Rêlo
Journal:  J Neurosci       Date:  1999-11-01       Impact factor: 6.167

2.  Distribution of GABA and neuropeptides in the human cerebral cortex. A light and electron microscopic study.

Authors:  W Y Ong; L J Garey
Journal:  Anat Embryol (Berl)       Date:  1991

3.  The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.

Authors:  H J Little; D J Nutt; S C Taylor
Journal:  Br J Pharmacol       Date:  1986-07       Impact factor: 8.739

4.  Differential increases in brain levels of neuropeptide Y and vasoactive intestinal polypeptide after kainic acid-induced seizures in the rat.

Authors:  J Marksteiner; G Sperk; D Maas
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989 Jan-Feb       Impact factor: 3.000

5.  Lack of effect of chronic carbamazepine on brain somatostatin in the rat.

Authors:  S R Weiss; T Nguyen; D R Rubinow; C J Helke; P K Narang; R M Post; D M Jacobowitz
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

6.  Repeated electroconvulsive shocks cause transient changes in rat hippocampal somatostatin and neuropeptide Y immunoreactivity and mRNA in situ hybridization signals.

Authors:  J Kragh; N Tønder; B R Finsen; J Zimmer; T G Bolwig
Journal:  Exp Brain Res       Date:  1994       Impact factor: 1.972

7.  Beta-endorphin, somatostatin, and prolactin levels in cerebrospinal fluid of epileptic patients after generalised convulsion.

Authors:  A Pitkänen; J Jolkkonen; P Riekkinen
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-10       Impact factor: 10.154
  7 in total

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