Literature DB >> 6140059

Demonstration of alpha 1s-adrenoceptors after exposure of the rat anococcygeus to benextramine.

J Coates, D F Weetman.   

Abstract

Sgd 101/75 (4(2-imidazoline-amino)-2-methylindazol-chlorhydrate) and noradrenaline exerted similar, full agonist effects on the alpha-adrenoceptors of the rat anococcygeus. Benextramine (30 microM for 30 min, followed by 20 washes over 30 min) abolished contractions of the anococcygeus to Sgd 101/75, but only reduced those to noradrenaline. Sgd 101/75 (400 microM) did not significantly reduce contractions of the benextramine-treated (30 microM) anococcygeus to noradrenaline. It is concluded that benextramine can replace phenoxybenzamine as the alkylating agent in the demonstration of alpha 1s-adrenoceptors in the rat anococcygeus.

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Year:  1983        PMID： 6140059      PMCID： PMC2045030          DOI： 10.1111/j.1476-5381.1983.tb10039.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors.

Authors:  J C Doxey; C F Smith; J M Walker
Journal:  Br J Pharmacol       Date:  1977-05       Impact factor: 8.739

2.  Prazosin, a selective antagonist of post-synaptic alpha-adrenoceptors [proceedings].

Authors:  D Cambridge; M J Davey; R Massingham
Journal:  Br J Pharmacol       Date:  1977-03       Impact factor: 8.739

3.  Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

Authors:  J M VAN ROSSUM
Journal:  Arch Int Pharmacodyn Ther       Date:  1963

4.  The effect on the isolated rabbit heart of vagal stimulation and its modification by cocaine, hexamethonium and ouabain.

Authors:  L M MCEWEN
Journal:  J Physiol       Date:  1956-03-28       Impact factor: 5.182

5.  Molecular properties of the adrenergic alpha receptor. 2. Optimum covalent inhibition by two different prototypes of polyamine disulfides.

Authors:  C Melchiorre; M S Yong; B G Benfey; B Belleau
Journal:  J Med Chem       Date:  1978-11       Impact factor: 7.446

6.  Occurrence of alpha 1s-adrenoceptors in the mouse but not in the rabbit isolated anococcygeus preparations.

Authors:  J Coates; D F Weetman
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

7.  The existence of a new subtype of alpha-adrenoceptor on the rat anococcygeus is revealed by SGD 101/75 and phenoxybenzamine.

Authors:  J Coates; U Jahn; D F Weetman
Journal:  Br J Pharmacol       Date:  1982-03       Impact factor: 8.739

8.  An in vitro quantitative analysis of the alpha adrenoceptor partial agonist activity of dobutamine and its relevance to inotropic selectivity.

Authors:  T P Kenakin
Journal:  J Pharmacol Exp Ther       Date:  1981-02       Impact factor: 4.030

9.  The rat anococcygeus muscle and its response to nerve stimulation and to some drugs.

Authors:  J S Gillespie
Journal:  Br J Pharmacol       Date:  1972-07       Impact factor: 8.739
  9 in total

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