Literature DB >> 6121597

The existence of a new subtype of alpha-adrenoceptor on the rat anococcygeus is revealed by SGD 101/75 and phenoxybenzamine.

J Coates, U Jahn, D F Weetman.   

Abstract

1 Noradrenaline and Sgd 101/75 (4(2-imidazoline-amino)-2-methylindazol-chlorhydrate) acted as full agonists in contracting the rat anococcygeus. 2 Very low concentrations of phenoxybenzamine (0.3 nM for 2-30 min) reduced preferentially the effects of Sgd 101/75. Preparations made insensitive to Sgd 101/75 by phenoxybenzamine still contracted to noradrenaline, this contraction occurring in the presence of high concentrations (400 microM) of Sgd 101/75. 3 It is concluded therefore that the alpha 1-adrenoceptor in this preparation is not a homogeneous entity and must be subdivided into at least two subtypes.

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Year:  1982        PMID： 6121597      PMCID： PMC2071563          DOI： 10.1111/j.1476-5381.1982.tb09172.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  5 in total

1.  Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

Authors:  J M VAN ROSSUM
Journal:  Arch Int Pharmacodyn Ther       Date:  1963

2.  The effect on the isolated rabbit heart of vagal stimulation and its modification by cocaine, hexamethonium and ouabain.

Authors:  L M MCEWEN
Journal:  J Physiol       Date:  1956-03-28       Impact factor: 5.182

3.  Effect of alpha-adrenergic agonists and antagonists on neurotransmission in the rat anococcygeus muscle.

Authors:  J Leighton; K R Butz; L L Parmeter
Journal:  Eur J Pharmacol       Date:  1979-09-01       Impact factor: 4.432

4.  Postsynaptic alpha-adrenoceptor subtypes in rabbit blood vessels and rat anococcygeus muscle studied in vitro.

Authors:  J R Docherty; K Starke
Journal:  J Cardiovasc Pharmacol       Date:  1981 Jul-Aug       Impact factor: 3.105

5.  The rat anococcygeus muscle and its response to nerve stimulation and to some drugs.

Authors:  J S Gillespie
Journal:  Br J Pharmacol       Date:  1972-07       Impact factor: 8.739
  5 in total
  10 in total

1.  Occurrence of alpha 1s-adrenoceptors in the mouse but not in the rabbit isolated anococcygeus preparations.

Authors:  J Coates; D F Weetman
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

2.  Cardiovascular aspects of pharmacology of berberine: I. Alpha-adrenoceptor blocking action of berberine in isolated rat anococcygeus muscle and rabbit aortic strip.

Authors:  B Cheng; L Y Luo; D C Fang; M X Jiang
Journal:  J Tongji Med Univ       Date:  1987

3.  Preferential antagonism by diltiazem of alpha 2-adrenoceptor mediated vasoconstrictor responses in perfused tail arteries of spontaneous hypertensive rats.

Authors:  P E Hicks; C Tierney; S Z Langer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-02       Impact factor: 3.000

4.  Sgd 101/75: cardiovascular effects in various animal preparations; interactions with vascular postjunctional alpha 1- and alpha 2-adrenoceptors.

Authors:  M J Mathy; M J Thoolen; P B Timmermans; P A van Zwieten
Journal:  Br J Pharmacol       Date:  1984-02       Impact factor: 8.739

5.  Demonstration of alpha 1s-adrenoceptors after exposure of the rat anococcygeus to benextramine.

Authors:  J Coates; D F Weetman
Journal:  Br J Pharmacol       Date:  1983-10       Impact factor: 8.739

6.  Differential effect of calcium entry blockers on alpha 1-adrenoceptor-mediated vasoconstriction in vivo.

Authors:  P B Timmermans; M J Mathy; B Wilffert; H O Kalkman; M J Thoolen; A de Jonge; J C van Meel; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-12       Impact factor: 3.000

7.  Alpha-adrenoceptor antagonism by apoyohimbine and some observations on the pharmacology of alpha-adrenoceptors in the rat anococcygeus and vas deferens.

Authors:  J C McGrath
Journal:  Br J Pharmacol       Date:  1984-08       Impact factor: 8.739

8.  Membrane potential responses to ionophoretically applied alpha-adrenoceptor agonists in the mouse anococcygeus muscle.

Authors:  W A Large
Journal:  Br J Pharmacol       Date:  1983-05       Impact factor: 8.739

9.  Evidence for two mechanisms of depolarization associated with alpha 1-adrenoceptor activation in the rat anococcygeus muscle.

Authors:  N G Byrne; W A Large
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739

10.  Pharmacological characterization of the postjunctional alpha-adrenoceptors of the rat isolated seminal vesicle.

Authors:  S I Sharif; S D Gokhale; S I Chandranath
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-05       Impact factor: 3.000
  10 in total

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