Literature DB >> 6135766

Treatment of cryptorchidism with pulsatile luteinizing hormone-releasing hormone (LH-RH).

E J Keogh, A MacKellar, S A Mallal, A G Dunn, S C McColm, C P Somerville, C Glatthaar, T Marshall, J Attikiouzel.   

Abstract

This preliminary report describes a new method of treating bilateral cryptorchidism that may modify the need for surgical intervention. Four of five boys (3 1/2, 3 1/2, 7, 11 and 12 1/2 years of age) given hourly subcutaneous pulses of luteinizing hormone-releasing hormone (LH-RH, 10 to 100 micrograms/day, given in a 3-min pulse every hour) showed evidence of testicular descent after 3 to 19 weeks. The battery-operated, programmable syringe driver was well tolerated by the boys, and the daily insertion of the scalp-vein needles was managed at home by their parents.

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Year:  1983        PMID: 6135766     DOI: 10.1016/s0022-3468(83)80102-x

Source DB:  PubMed          Journal:  J Pediatr Surg        ISSN: 0022-3468            Impact factor:   2.545


  2 in total

Review 1.  Luteinizing hormone-releasing hormone and its analogues: a review of biological properties and clinical uses.

Authors:  B J Furr; J R Woodburn
Journal:  J Endocrinol Invest       Date:  1988 Jul-Aug       Impact factor: 4.256

2.  Therapeutic results in cryptorchidism after combination therapy with LH-RH nasal spray and hCG.

Authors:  J Waldschmidt; M el-Dessouky; A Priefer
Journal:  Eur J Pediatr       Date:  1987       Impact factor: 3.183

  2 in total

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