Literature DB >> 6133580

Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease.

C C Smith, D M Bowen, N R Sims, D Neary, A N Davison.   

Abstract

Tissue prisms prepared from neurosurgical samples of temporal neocortex of Alzheimer and control patients, upon depolarization preferentially released aspartate, glutamate and gamma-aminobutyrate (GABA). The Alzheimer and control samples did not significantly differ in the pattern of amino acid release, although acetylcholine synthesis by the Alzheimer tissue prisms was greatly reduced. There was no correlation between the efflux of any amino and acetylcholine synthesis. These observations suggest that in Alzheimer's disease there are no major changes in the extracellular concentrations of these putative amino acid transmitters.

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Year:  1983        PMID： 6133580     DOI： 10.1016/0006-8993(83)91131-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  5 in total

1.  Postmortem- and cryostability of the potassium-evoked release of [3H]5-hydroxytryptamine from rat cerebral cortical miniprisms.

Authors:  C J Fowler; G Thorell; I Fagervall
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

2.  Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease.

Authors:  Shirley W Y Tsang; Harry V Vinters; Jeffrey L Cummings; Peter T-H Wong; Christopher P L-H Chen; Mitchell K P Lai
Journal:  Neurobiol Aging       Date:  2007-04-11       Impact factor: 4.673

3.  Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.

Authors:  C C Smith; D M Bowen; P T Francis; J S Snowden; D Neary
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-05       Impact factor: 10.154

Review 4.  A potential role for apoptosis in neurodegeneration and Alzheimer's disease.

Authors:  C W Cotman; A J Anderson
Journal:  Mol Neurobiol       Date:  1995-02       Impact factor: 5.590

5.  Loss of cortical GABA uptake sites in Alzheimer's disease.

Authors:  M D Simpson; A J Cross; P Slater; J F Deakin
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575
  5 in total

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