| Literature DB >> 6131169 |
J P Capron, J L Gineston, M A Herve, A Braillon.
Abstract
The effect of metronidazole on liver function tests was studied in patients given total parenteral nutrition (TPN) for an acute attack of Crohn's disease. In those receiving TPN and metronidazole, serum activities of alkaline phosphatase and gamma-glutamyl-transferase decreased or remained normal after 30 days of TPN. In contrast, serum activities of these enzymes increased significantly after 30 days of TPN alone. These results suggest that intrahepatic cholestasis associated with TPN may be related to intestinal overgrowth of anaerobic bacteria.Entities:
Mesh：
Substances：
Year: 1983 PMID： 6131169 DOI： 10.1016/s0140-6736(83)91442-3
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321