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Literature DB >> 22541695

Approach to a patient with elevated serum alkaline phosphatase.

Abstract

Cholestasis develops either from a defect in bile synthesis, impairment in bile secretion, or obstruction to bile flow, and is characterized by an elevated serum alkaline phosphatase and gamma-glutamyltransferase disproportionate to elevation of aminotransferase enzymes. Key elements to the diagnostic workup include visualization of the biliary tree by cholangiography and evaluation of liver histology. The hope is that recent advances in understanding the genetic factors and immune mechanisms involved in the pathogenesis of cholestasis will lead to newer therapeutic interventions in the treatment of these diseases.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Alkaline Phosphatase

Year: 2012 PMID： 22541695 PMCID： PMC3341633 DOI： 10.1016/j.cld.2012.03.012

Source DB: PubMed Journal: Clin Liver Dis ISSN： 1089-3261 Impact factor: 6.126

202 in total

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Journal: Hepatogastroenterology Date: 1999 Jan-Feb

2. Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis.

Authors: Renée Eugénie Poupon; Keith D Lindor; Albert Parés; Olivier Chazouillères; Raoul Poupon; E Jenny Heathcote
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Journal: Clin Rev Allergy Immunol Date: 2005-04 Impact factor: 8.667

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Journal: J Hepatol Date: 2000 Impact factor: 25.083

5. Paroxetine in the treatment of severe non-dermatological pruritus: a randomized, controlled trial.

Authors: Zbigniew Zylicz; Malgorzata Krajnik; Adriaan Alistar van Sorge; Massimo Costantini
Journal: J Pain Symptom Manage Date: 2003-12 Impact factor: 3.612

6. A prospective study of 18 patients with cholestasis of pregnancy.

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Journal: Am J Obstet Gynecol Date: 1982-03-15 Impact factor: 8.661

7. Choledochal cyst disease in children and adults: a 30-year single-institution experience.

Authors: Barish H Edil; John L Cameron; Sushanth Reddy; Yingwei Lum; Pamela A Lipsett; Hari Nathan; Timothy M Pawlik; Michael A Choti; Christopher L Wolfgang; Richard D Schulick
Journal: J Am Coll Surg Date: 2008-03-17 Impact factor: 6.113

Review 8. Diagnosis and management of acute cholangitis.

Authors: John G Lee
Journal: Nat Rev Gastroenterol Hepatol Date: 2009-08-04 Impact factor: 46.802

9. Treatment of pruritus of primary biliary cirrhosis with rifampin.

Authors: A Podesta; P Lopez; R Terg; F Villamil; D Flores; R Mastai; C B Udaondo; J P Companc
Journal: Dig Dis Sci Date: 1991-02 Impact factor: 3.199

10. Specific pruritic diseases of pregnancy. A prospective study of 3192 pregnant women.

Authors: D Roger; L Vaillant; A Fignon; F Pierre; Y Bacq; J F Brechot; M C Grangeponte; G Lorette
Journal: Arch Dermatol Date: 1994-06

25 in total

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Authors: Brittany L Carroll; Martin Fleisher; Melissa S Pessin; Lakshmi V Ramanathan
Journal: J Appl Lab Med Date: 2017-11-01

3. Rhythmic Fluctuations in Levels of Liver Enzymes During Menstrual Cycles of Healthy Women and Effects of Body Weight.

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Review 4. A Systematic Approach to Patients with Jaundice.

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Journal: Semin Intervent Radiol Date: 2016-12 Impact factor: 1.513

5. Thrombocytopenia, anasarca, and severe inflammation.

Authors: Amanallah Montazeripouragha; Christine M Campbell; James Russell; Nadia Medvedev; Daniel R Owen; Alison Harris; Fergal Donnellan; Iain McCormick; David C Fajgenbaum; Luke Y C Chen
Journal: Am J Hematol Date: 2022-07-19 Impact factor: 13.265

6. Association between alendronate, serum alkaline phosphatase level, and heterotopic ossification in individuals with spinal cord injury.

Authors: Avraam Ploumis; Jayne M Donovan; Mobolaji O Olurinde; Dana M Clark; Jason C Wu; Douglas J Sohn; Kevin C O'Connor
Journal: J Spinal Cord Med Date: 2014-05-13 Impact factor: 1.985

Review 7. Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy.

Authors: Treta Purohit; Mitchell S Cappell
Journal: World J Hepatol Date: 2015-05-08

8. Significantly Elevated Liver Alkaline Phosphatase in Congestive Heart Failure.

Authors: Leonid Shamban; Brijesh Patel; Michael Williams
Journal: Gastroenterology Res Date: 2014-05-02

9. Ethanol extracts collected from the Styela clava tunic alleviate hepatic injury induced by carbon tetrachloride (CCl₄) through inhibition of hepatic apoptosis, inflammation, and fibrosis.

Authors: Eun Kyoung Koh; Ji Eun Kim; Sung Hwa Song; Ji Eun Sung; Hyun Ah Lee; Kil Soo Kim; Jin Tae Hong; Dae Youn Hwang
Journal: J Toxicol Pathol Date: 2017-08-28 Impact factor: 1.628

10. Generation of monoclonal antibody MS17-57 targeting secreted alkaline phosphatase ectopically expressed on the surface of gastrointestinal cancer cells.

Authors: Ming Li; Jianpeng Gao; Runhua Feng; Yuling Wang; Xuehua Chen; Jianyu Sun; Dongqing Zhang; Zhenggang Zhu; Lee M Ellis; Mason Lu; Jeffrey E Lee; Zhenqing Feng; Bingya Liu
Journal: PLoS One Date: 2013-10-15 Impact factor: 3.240