| Literature DB >> 6125773 |
J M Goldman, A S Baughan, D M McCarthy, A M Worsley, J M Hows, E C Gordon-Smith, D Catovsky, J R Batchelor, A W Goolden, D A Galton.
Abstract
In 1979 two patients with Philadelphia (Ph1)-chromosome-positive chronic granulocytic leukaemia (CGL) were treated with chemoradiotherapy and transplantation of bone marrow from their respective identical twins. Subsequently twelve patients with Ph1-positive CGL in chronic phase were treated with chemoradiotherapy followed by transplantation of bone marrow from their HLA-identical sibs. Two of the fourteen patients have died of complications of the transplant procedure; twelve patients are alive and well. All the survivors have normal or nearly normal blood counts; there is no evidence of recurrent leukaemia or Ph1-positive cells in any patient after follow-up periods ranging from 97 to 1112 days. Bone-marrow transplantation should be considered in the management of any young patient with CGL who has a suitable marrow donor.Entities:
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Year: 1982 PMID： 6125773 DOI： 10.1016/s0140-6736(82)92736-2
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321