| Literature DB >> 25852053 |
Abstract
The introduction of tyrosine kinase inhibitors (TKIs), a treatment of chronic myelogenous leukemia (CML), has largely replaced curative strategies based on allogeneic stem cell transplantation (SCT). Nevertheless, SCT still remains an option for accelerated/blastic-phase and selected chronic-phase CML. Transplant outcomes can be optimized by peritransplant TKIs, conditioning regimen, BCR-ABL monitoring, and relapse management. Controversies exist in transplant timing, pediatric CML, alternative donors, and economics. SCT continues to serve as a platform of "operational cure" for CML with TKIs and immunotherapies.Entities:
Mesh:
Year: 2015 PMID: 25852053 PMCID: PMC4440879 DOI: 10.1182/blood-2014-10-567784
Source DB: PubMed Journal: Blood ISSN: 0006-4971 Impact factor: 22.113