Literature DB >> 612460

Comparative mammalian metabolism of vinyl chloride and vinylidene chloride in relation to oncogenic potential.

D E Hathway.   

Abstract

Elucidation of the role of vinyl chloride metabolites in the various reaction sequences which comprise the metabolic pathway, including the interaction of reactive metabolities with some purine and pyrimidine residues of target-organ DNA, provides some explanation for the (oncogenic) properties associated with the original substance. Comparative investigation of the biological fate of vinylidene chloride reveals an agent of low oncogenic potential which is likely to be damaging only under special circumstances, and species differences which suggest that the mouse is more susceptible than the rat towards vinylidene chloride oncogenicity.

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Year:  1977        PMID： 612460      PMCID： PMC1475329          DOI： 10.1289/ehp.772155

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  10 in total

1.  Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation.

Authors:  H Greim; G Bonse; Z Radwan; D Reichert; D Henschler
Journal:  Biochem Pharmacol       Date:  1975-11-01       Impact factor: 5.858

2.  Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride.

Authors:  A Barbin; H Brésil; A Croisy; P Jacquignon; C Malaveille; R Montesano; H Bartsch
Journal:  Biochem Biophys Res Commun       Date:  1975-11-17       Impact factor: 3.575

3.  The biological fate in rats of vinyl chloride in relation to its oncogenicity.

Authors:  T Green; D E Hathway
Journal:  Chem Biol Interact       Date:  1975-12       Impact factor: 5.192

4.  On the possible mechanism of carcinogenic action of vinyl chloride.

Authors:  B L Van Duuren
Journal:  Ann N Y Acad Sci       Date:  1975-01-31       Impact factor: 5.691

5.  Fluorescent adenosine and cytidine derivatives.

Authors:  J R Barrio; J A Secrist; N J Leonard
Journal:  Biochem Biophys Res Commun       Date:  1972-01-31       Impact factor: 3.575

6.  Inactivation of bacteriophage T7 by mono- and difunctional sulphur mustards in relation to cross-linking and depurination of bacteriophage DNA.

Authors:  P D Lawley; J H Lethbridge; P A Edwards; K V Shooter
Journal:  J Mol Biol       Date:  1969-01-14       Impact factor: 5.469

7.  Human, rat and mouse liver-mediated mutagenicity of vinyl chloride in S. typhimurium strains.

Authors:  H Bartsch; C Malaveille; R Montesano
Journal:  Int J Cancer       Date:  1975-03-15       Impact factor: 7.396

8.  Cytochrome P-450 and the metabolism of vinyl chloride.

Authors:  A G Salmon
Journal:  Cancer Lett       Date:  1976-11       Impact factor: 8.679

9.  Electrochemical analysis of the carboxy-14C-labelled aliphatic carboxylic acid metabolites resulting from tracer studies.

Authors:  G H Walker; D E Hathway
Journal:  Biochem J       Date:  1977-11-01       Impact factor: 3.857

10.  Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide.

Authors:  J McCann; V Simmon; D Streitwieser; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205
  10 in total
  8 in total

1.  Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways.

Authors:  Pamela E Blackshear; Arun R Pandiri; Hiroaki Nagai; Sachin Bhusari; Hue-Hua Hong; Thai-Vu T Ton; Natasha P Clayton; Michael Wyde; Keith R Shockley; Shyamal D Peddada; Kevin E Gerrish; Robert C Sills; Mark J Hoenerhoff
Journal:  Toxicol Pathol       Date:  2014-06-23       Impact factor: 1.902

2.  Time-related variation of non-protein sulfhydryl concentrations in rat tissues and human blood.

Authors:  R J Jaeger
Journal:  Int Arch Occup Environ Health       Date:  1979-01-15       Impact factor: 3.015

3.  Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation.

Authors:  Schantel A Hayes; Arun R Pandiri; Thai-vu T Ton; Hue-Hua L Hong; Natasha P Clayton; Keith R Shockley; Shyamal D Peddada; Kevin Gerrish; Michael Wyde; Robert C Sills; Mark J Hoenerhoff
Journal:  Toxicol Pathol       Date:  2015-12-17       Impact factor: 1.902

4.  DNA adducts of halogenated hydrocarbons.

Authors:  H M Bolt; R J Laib; H Peter; H Ottenwälder
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

5.  Vinyl chloride monomer (VCM) induces high occurrence of neural tube defects in embryonic mouse brain during neurulation.

Authors:  Hongyu Quan; Teng Ma; Xianxian Zhao; Baixiong Zhao; Yunlai Liu; Hongli Li
Journal:  Cell Mol Neurobiol       Date:  2014-03-25       Impact factor: 5.046

6.  Mechanisms of vinyl chloride carcinogenicity/mutagenicity.

Authors:  D E Hathaway
Journal:  Br J Cancer       Date:  1981-10       Impact factor: 7.640

7.  Haloethylene-related compounds of industrial, environmental, and medical significance.

Authors:  H S Posner; H L Falk
Journal:  Environ Health Perspect       Date:  1977-12       Impact factor: 9.031

8.  1,1-Dichloroethylene hepatotoxicity: proposed mechanism of action and distribution and binding of 14C radioactivity following inhalation exposure in rats.

Authors:  R J Jaeger; L G Shoner; L Coffman
Journal:  Environ Health Perspect       Date:  1977-12       Impact factor: 9.031
  8 in total

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