| Literature DB >> 13927 |
Abstract
The oxidation of vinyl chloride to non-volatile products is dependent on NADPH and microsomal enzymes. The addition of vinyl chloride to microsomes causes a Type 1 spectra shift, similar to that seen for phenobarbital [11[ which indicates the direct involvement of a cytochrome P-450 species; this difference spectrum is characteristic of substrate binding to this type of enzyme. A glutathione conjugate is probably formed, perhaps via a reactive intermediate.Entities:
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Year: 1976 PMID： 13927 DOI： 10.1016/s0304-3835(76)80019-5
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679