Literature DB >> 6124293

Inhibition of adrenaline-induced platelet aggregation by the alpha-adrenoceptor blocking drug benextramine.

B Belleau, B G Benfey, C Melchiorre, M Montambault.   

Abstract

1 The activity of the irreversible alpha-adrenoceptor blocking drug, benextramine, was determined in human platelets. 2 Compared to its postsynaptic and presynaptic alpha-adrenoceptor blocking potency, benextramine had a very low potency as an antagonist of adrenaline-induced platelet aggregation. 3 The results confirm the previous observation with the irreversible alpha-adrenoceptor blocking drug, phenoxybenzamine, that platelet alpha-adrenoceptors differ from postsynaptic and presynaptic alpha-adrenoceptors.

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Year:  1982        PMID： 6124293      PMCID： PMC2071787          DOI： 10.1111/j.1476-5381.1982.tb09214.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  18 in total

1.  Platelet aggregation: Part I Some effects of the adenosine phosphates, thrombin, and cocaine upon platelet adhesiveness.

Authors:  J R O'brien
Journal:  J Clin Pathol       Date:  1962-09       Impact factor: 3.411

2.  Characterization of alpha- and beta-adrenergic receptors linked to human platelet adenylate cyclase.

Authors:  K H Jakobs; W Saur; G Schultz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-05       Impact factor: 3.000

3.  Molecular properties of the adrenergic alpha receptor. 2. Optimum covalent inhibition by two different prototypes of polyamine disulfides.

Authors:  C Melchiorre; M S Yong; B G Benfey; B Belleau
Journal:  J Med Chem       Date:  1978-11       Impact factor: 7.446

4.  Inhibition of adrenergic vasoconstriction by quinidine.

Authors:  P G Schmid; L D Nelson; A L Mark; D D Heistad; F M Abboud
Journal:  J Pharmacol Exp Ther       Date:  1974-01       Impact factor: 4.030

5.  Effect of phentolamine on noradrenaline uptake and release.

Authors:  K Starke; H Montel; J Wagner
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1971

6.  Studies on the effect of adrenergic blocking drugs on catecholamine-induced platelet aggregation and uptake of noradrenaline and 5-hydroxytryptamine.

Authors:  S Bygdeman; O Johnsen
Journal:  Acta Physiol Scand       Date:  1969 Jan-Feb

7.  Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. I. Role of neuronal and extraneuronal uptake and of alpha presynaptic receptors.

Authors:  L Cubeddu; E M Barnes; S Z Langer; N Weiner
Journal:  J Pharmacol Exp Ther       Date:  1974-09       Impact factor: 4.030

8.  The effects of alpha adrenergic agents on human platelet aggregation.

Authors:  C Y Hsu; D R Knapp; P V Halushka
Journal:  J Pharmacol Exp Ther       Date:  1979-03       Impact factor: 4.030

9.  Potentiation of platelet aggregation by adrenaline.

Authors:  G V Born; D C Mills; G C Roberts
Journal:  J Physiol       Date:  1967-07       Impact factor: 5.182

10.  A COMPARISON OF PLATELET AGGREGATION PRODUCED BY SEVEN COMPOUNDS AND A COMPARISON OF THEIR INHIBITORS.

Authors:  J R O'BRIEN
Journal:  J Clin Pathol       Date:  1964-05       Impact factor: 3.411
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