Literature DB >> 6124259

Binding of [3H]ADTN to rat striatal membranes.

W W Templeton, G N Woodruff.   

Abstract

The conformationally restricted dopamine analogue ADTN binds in a specific saturable manner to rat striatal membranes. Analysis of the data suggests a single binding site. Binding of [3H]ADTN is displaced by a wide range of dopamine agonists and antagonists (both typical and atypical). The potency of ADTN derivatives to displace [3H]ADTN correlates well with their activity as agonists in other tests both in vivo and in vitro.

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Year:  1982        PMID： 6124259     DOI： 10.1016/0006-2952(82)90391-4

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  2 in total

1.  A comparison of some of the properties of the [3H]-sulpiride binding site in soluble and native membrane preparations of dog striatum.

Authors:  W W Templeton; G N Woodruff
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

2.  Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin.

Authors:  T B Mulder; J B de Vries; D Dijkstra; J W Wiechers; C J Grol; A S Horn
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-11       Impact factor: 3.000
  2 in total

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