Receptors for bradykinin in murine peritoneal macrophages: modulation of short-term spreading.

The order of potency of bradykinin (bk) and four analogues, with respect to their modulation of peritoneal macrophage short-term spreading, suggests the presence of two peptide receptors in these cells which are responsible for antagonistic effects. Spreading inhibition and stimulation are mediated by the B1- and B2-types respectively. The implications of these results are highlighted in view of the hypothesis that the anti-inflammatory compound of the 1500--1000 molecular weight peptide fraction purified from malignant cell culture supernatants could be a kinin metabolite and a feedback mediator of inflammatory reactions.