Literature DB >> 191908

Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents.

M A Ondetti, B Rubin, D W Cushman.   

Abstract

A hypothetical model of the active site of angiotensin-converting enzyme, based on known chemical and kinetic properties of the enzyme, has enabled us to design a new class of potent and specific inhibitors. These compounds, carboxyalkanoyl and mercaptoalkanoyl derivatives of proline, inhibit the contractile response of guinea pig ileal strip to angiotensin I and augment its response to bradykinin. When administered orally to rats, these agents inhibit the pressor effect of angiotensin I, augment the vasodepressor effect of bradykinin, and lower blood pressure in a model of renovascular hypertension.

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Year:  1977        PMID： 191908     DOI： 10.1126/science.191908

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  212 in total

Review 1.  Historical perspective of the renin-angiotensin system.

Authors:  John E Hall
Journal:  Mol Biotechnol       Date:  2003-05       Impact factor: 2.695

2.  Mass spectral fragmentation reactions of angiotensin-converting enzyme (ACE) inhibitors.

Authors:  David J Burinsky; Scott L Sides
Journal:  J Am Soc Mass Spectrom       Date:  2004-09       Impact factor: 3.109

3.  Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7).

Authors:  Carlos M Ferrario; Sarfaraz Ahmad; Janae Joyner; Jasmina Varagic
Journal:  Adv Pharmacol       Date:  2010

Review 4.  Bioactive peptides of animal origin: a review.

Authors:  Z F Bhat; Sunil Kumar; Hina Fayaz Bhat
Journal:  J Food Sci Technol       Date:  2015-01-21       Impact factor: 2.701

5.  Novel activity of angiotensin-converting enzyme. Hydrolysis of cholecystokinin and gastrin analogues with release of the amidated C-terminal dipeptide.

Authors:  P Dubreuil; P Fulcrand; M Rodriguez; H Fulcrand; J Laur; J Martinez
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

Review 6.  Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treatment of sensory receptor dysfunction.

Authors:  R I Henkin
Journal:  Drug Saf       Date:  1994-11       Impact factor: 5.606

7.  The effect of captopril on sodium appetite in adrenalectomized and deoxycorticosterone-treated rats.

Authors:  R M Elfont; J T Fitzsimons
Journal:  J Physiol       Date:  1985-08       Impact factor: 5.182

Review 8.  [The renin-angiotensin system in cardiovascular diseases].

Authors:  C Unterberg; H Kreuzer; A B Buchwald
Journal:  Med Klin (Munich)       Date:  1998-07-15

9.  A glutamate residue contributes to the exopeptidase specificity in aminopeptidase A.

Authors:  G Vazeux; X Iturrioz; P Corvol; C Llorens-Cortes
Journal:  Biochem J       Date:  1998-09-01       Impact factor: 3.857

10.  Effects of bradykinin and various synthetic analogs on rat polymorphonuclear chemotaxis.

Authors:  M Roch-Arveiller; D Regoli; J P Giroud
Journal:  Agents Actions       Date:  1981-11
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