Plasma protein binding of fentanyl: the effect of hyperlipoproteinaemia and chronic renal failure.

Hyperlipoproteinaemic patients with raised pre beta-, or pre beta- and beta-lipoprotein fractions showed a significant (P less than 0.001) increase in binding of fentanyl to whole plasma, compared with normal subjects. The presence of chylomicra had no significant effect on binding. In patients with chronic renal failure, a correlation of probability P less than 0.07 was found between percent binding and concentrations of pre beta-lipoprotein (P = 0.001), serum albumin (P = 0.0101), total protein minus albumin (P = 0.0576) and beta-lipoprotein (P = 0.0625). There was no significant correlation of binding with elevation of alpha- or gamma-globulins, with urea or creatinine concentrations, or with age or sex (P greater than 0.223). The magnitude of changes in the free fraction found in these patients should not produce a clinical effect as the total distribution volume of fentanyl exceeds 200 litres.