| Literature DB >> 2872242 |
C F McDonald, S A Thomson, N C Scott, W Scott, I W Grant, G K Crompton.
Abstract
A 14-year-old previously fit schoolboy was admitted with staphylococcal pneumonia secondary to influenza A infection. His condition deteriorated as he developed adult respiratory distress syndrome (ARDS); during a stormy recovery exceptionally high doses of benzodiazepines and opiates were given in order to suppress voluntary breathing during a successful period of assisted ventilation. It is possible that benzodiazepine-opiate antagonism developed. Subsequent studies in laboratory mice indicate that the respiratory depressant effects of morphine can be antagonized by prior treatment with lorazepam.Entities:
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Year: 1986 PMID： 2872242 DOI： 10.1007/bf00315369
Source DB: PubMed Journal: Intensive Care Med ISSN： 0342-4642 Impact factor: 17.440