Literature DB >> 6118761

Experimental transmission of legionnaires' disease by exposure to aerosols of Legionella pneumophila.

A Baskerville, R B Fitzgeorge, M Broster, P Hambleton, P J Dennis.   

Abstract

Pyrexia and pneumonia developed in guinea-pigs after exposure to aerosols of Legionella pneumophila in a Henderson apparatus. Mortality was high 1-3 days after exposure. Histopathological changes were of an acute fibrinopurulent pneumonia, with widespread fibrin exudation and accumulation of neutrophils and macrophages in alveoli-lesions similar to those of legionella pneumonia in man. Rhesus monkeys given low doses of bacteria had slight fever and mild histological lesions in the lungs. Aerosol infection of these species offers suitable experimental models of legionnaires' disease.

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Year:  1981        PMID： 6118761     DOI： 10.1016/s0140-6736(81)92803-8

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  28 in total

Review 1.  Molecular pathogenesis of infections caused by Legionella pneumophila.

Authors:  Hayley J Newton; Desmond K Y Ang; Ian R van Driel; Elizabeth L Hartland
Journal:  Clin Microbiol Rev       Date:  2010-04       Impact factor: 26.132

2.  Rapid escape of the dot/icm mutants of Legionella pneumophila into the cytosol of mammalian and protozoan cells.

Authors:  Maëlle Molmeret; Marina Santic'; Rexford Asare; Reynold A Carabeo; Yousef Abu Kwaik
Journal:  Infect Immun       Date:  2007-04-16       Impact factor: 3.441

3.  A community outbreak of Legionnaires' disease associated with a cooling tower in Vic and Gurb, Catalonia (Spain) in 2005.

Authors:  M R Sala Ferré; C Arias; J M Oliva; A Pedrol; M García; T Pellicer; P Roura; A Domínguez
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2008-08-28       Impact factor: 3.267

4.  The effect of oxygen-dependent antimicrobial systems on strains of Legionella pneumophila of different virulence.

Authors:  R I Jepras; R B Fitzgeorge
Journal:  J Hyg (Lond)       Date:  1986-08

5.  Direct activation of human monocyte-derived macrophages by a bacterial glycoprotein extract inhibits the intracellular multiplication of virulent Legionella pneumophila serogroup 1.

Authors:  P Rajagopalan; E Dournon; J L Vildé; J J Pocidalo
Journal:  Infect Immun       Date:  1987-09       Impact factor: 3.441

Review 6.  Legionnaires disease: historical perspective.

Authors:  W C Winn
Journal:  Clin Microbiol Rev       Date:  1988-01       Impact factor: 26.132

7.  Control of Legionella pneumophila in a hospital water system by chlorine dioxide.

Authors:  J T Walker; C W Mackerness; D Mallon; T Makin; T Williets; C W Keevil
Journal:  J Ind Microbiol       Date:  1995-10

8.  A comparison of aerosol and intragastric routes of infection with Listeria spp.

Authors:  P Bracegirdle; A A West; M S Lever; R B Fitzgeorge; A Baskerville
Journal:  Epidemiol Infect       Date:  1994-02       Impact factor: 2.451

9.  Growth temperature reversibly modulates the virulence of Legionella pneumophila.

Authors:  W S Mauchline; B W James; R B Fitzgeorge; P J Dennis; C W Keevil
Journal:  Infect Immun       Date:  1994-07       Impact factor: 3.441

10.  Influence of iron-limited continuous culture on physiology and virulence of Legionella pneumophila.

Authors:  B W James; W S Mauchline; R B Fitzgeorge; P J Dennis; C W Keevil
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441
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