Literature DB >> 6117945

Tetrahydrobiopterin in striatum: localization in dopamine nerve terminals and role in catecholamine synthesis.

R A Levine, L P Miller, W Lovenberg.   

Abstract

The hydroxylase cofactor, tetrahydrobiopterin, and its biosynthetic system are localized in dopaminergic nerve terminals in the striatum. This conclusion is based on the nearly equivalent loss of tyrosine hydroxylase and tetrahydrobiopterin and its initial biosynthetic enzyme, guanosine triphosphate cyclohydrolase, after injection of 6-hydroxydopamine into the substantia nigra. The role of the hydroxylase cofactor in the regulation of dopamine synthesis is reassessed.

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Year:  1981        PMID： 6117945     DOI： 10.1126/science.6117945

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  24 in total

1.  Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts.

Authors:  C Bencsics; S R Wachtel; S Milstien; K Hatakeyama; J B Becker; U J Kang
Journal:  J Neurosci       Date:  1996-07-15       Impact factor: 6.167

2.  Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.

Authors:  Ian Cook; Ting Wang; Thomas S Leyh
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-19       Impact factor: 11.205

Review 3.  Tyrosine hydroxylase replacement in experimental Parkinson's disease with transvascular gene therapy.

Authors:  William M Pardridge
Journal:  NeuroRx       Date:  2005-01

Review 4.  GTP cyclohydrolase I gene, tetrahydrobiopterin, and tyrosine hydroxylase gene: their relations to dystonia and parkinsonism.

Authors:  T Nagatsu; H Ichinose
Journal:  Neurochem Res       Date:  1996-02       Impact factor: 3.996

5.  Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.

Authors:  R J Mandel; K G Rendahl; S K Spratt; R O Snyder; L K Cohen; S E Leff
Journal:  J Neurosci       Date:  1998-06-01       Impact factor: 6.167

6.  Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease.

Authors:  Hiroshi Ichinose; Ken-Ichi Inoue; Shinobu Arakawa; Yuki Watanabe; Hiroki Kurosaki; Shoko Koshiba; Eldbjorg Hustad; Masahiko Takada; Jan O Aasly
Journal:  J Neural Transm (Vienna)       Date:  2017-09-01       Impact factor: 3.575

7.  "7-tetrahydrobiopterin," a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydroxylases.

Authors:  M D Davis; P Ribeiro; J Tipper; S Kaufman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

8.  Simultaneous determination of in vivo hydroxylation of tyrosine and tryptophan in rat striatum by microdialysis-HPLC: relationship between dopamine and serotonin biosynthesis.

Authors:  H Hashiguti; D Nakahara; W Maruyama; M Naoi; T Ikeda
Journal:  J Neural Transm Gen Sect       Date:  1993

9.  Inhibition of striatal tyrosine hydroxylase by low concentrations of apomorphine.

Authors:  G Laschinski; B Kittner; M Bräutigam
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-09       Impact factor: 3.000

10.  Biopterin in Parkinson's disease.

Authors:  A P Moore; P O Behan; W Jacobson; W L Armarego
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-01       Impact factor: 10.154
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