Literature DB >> 6110823

Is thyrotropin releasing hormone an endogenous ergotropic substance in the brain?

G Metcalf, P W Dettmar.   

Abstract

The neuropharmacological profile for thyrotropin releasing hormone (TRH) has been compared with various other types of central nervous system stimulants, and the results of the comparison, considered together with the results obtained by other workers, suggest that TRH may function as an endogenous ergotropic substance. Its ergotropic properties suggest that TRH analogues with better biological stability than the parent compound may be useful agents for treating some psychiatric disorders; for hastening the recovery of consciousness and respiration after anaesthesia; for treating narcotic overdosage or dependence, narcolepsy, minimal brain damage, and various neuromuscular disorders; and for aiding the diagnosis of "brain death".

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Year:  1981        PMID： 6110823     DOI： 10.1016/s0140-6736(81)92035-3

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  7 in total

Review 1.  Role of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feeding.

Authors:  Y Taché; H Yang; M Miampamba; V Martinez; P Q Yuan
Journal:  Auton Neurosci       Date:  2006-03-06       Impact factor: 3.145

2.  Changes in the behavioural response to a TRH analogue following chronic amitriptyline treatment and repeated electroconvulsive shock in the rat.

Authors:  G W Bennett; A R Green; C Lighton; C A Marsden
Journal:  Br J Pharmacol       Date:  1986-05       Impact factor: 8.739

3.  Controlled acute trial of a thyrotrophin releasing hormone analogue (RX77368) in motor neuron disease.

Authors:  R J Guiloff; D J Eckland; C Demaine; R C Hoare; K D MacRae; S L Lightman
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-10       Impact factor: 10.154

4.  Electrophysiological observations in patients with motor neuron disease receiving a thyrotropin releasing hormone analogue (RX77368).

Authors:  R J Guiloff; E Stålberg; D J Eckland; S L Lightman
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-12       Impact factor: 10.154

5.  Acute effects of high-dose thyrotropin releasing hormone infusions in Alzheimer's disease.

Authors:  A M Mellow; T Sunderland; R M Cohen; B A Lawlor; J L Hill; P A Newhouse; M R Cohen; D L Murphy
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

6.  The effects of TRH analogues on cerebral ischaemia produced by middle cerebral artery occlusion in the rat.

Authors:  J Shrewsbury-Gee; R H Lye; A Latham; P Slater
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

7.  Breakpoint mapping and haplotype analysis of translocation t(1;12)(q43;q21.1) in two apparently independent families with vascular phenotypes.

Authors:  Tiia Maria Luukkonen; Mana M Mehrjouy; Minna Pöyhönen; Anna-Kaisa Anttonen; Päivi Lahermo; Pekka Ellonen; Lars Paulin; Niels Tommerup; Aarno Palotie; Teppo Varilo
Journal:  Mol Genet Genomic Med       Date:  2017-11-23       Impact factor: 2.183
  7 in total

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