Literature DB >> 6110575

LH-RH agonists and antagonists.

A V Schally, D H Coy, A Arimura.   

Abstract

Large doses of stimulatory analogues of luteinizing hormone-releasing hormone (LH-RH) caused paradoxical antifertility effects. These effects are being utilized for the possible development of contraceptive methods. Several inhibitory analogues of LH-RH have been tested in men and women and shown to be active. The synthetic approach based on inhibitory analogues of LH-RH has been proven to be feasible for development of new methods of birth control. Continued research and testing along these lines may lead to the development of contraceptives based on inhibitory analogues of LH-RH that could be conveniently applied as a nasal spray and could be free of undesirable side effects.

Entities:  

Keywords:  Biology; Contraception; Contraception Research; Endocrine System; Family Planning; Female Contraception; Gonadotropins; Hormone Antagonists--analysis; Hormones; Literature Review; Male Contraception; Physiology; Pituitary Hormone Releasing Hormones--analysis

Mesh：

Substances：

Year:  1980        PMID： 6110575     DOI： 10.1002/j.1879-3479.1980.tb00507.x

Source DB:  PubMed          Journal:  Int J Gynaecol Obstet        ISSN： 0020-7292            Impact factor:   3.561


  19 in total

Review 1.  [Pulsatile therapy with LHRH].

Authors:  M H Birkhäuser
Journal:  Arch Gynecol Obstet       Date:  1989       Impact factor: 2.344

2.  Synthetic peptide with inhibin-like activity preferentially inhibits follitropin secretion in comparison with lutropin-releasing hormone antagonists.

Authors:  M R Sairam; K Ramasharma; C H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

3.  Antagonists of luteinizing hormone releasing hormone bind to rat mast cells and induce histamine release.

Authors:  K Sundaram; A Didolkar; R Thau; M Chaudhuri; F Schmidt
Journal:  Agents Actions       Date:  1988-12

4.  Radioimmunoassay for 6-D-tryptophan analog of luteinizing hormone-releasing hormone: measurement of serum levels after administration of long-acting microcapsule formulations.

Authors:  M Mason-Garcia; S Vigh; A M Comaru-Schally; T W Redding; A Somogyvari-Vigh; J Horvath; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

5.  An oriented phase-II trial of D-Trp6-LH-RH in patients with prostatic carcinoma.

Authors:  G Mathé; M L Vo Van; J Duchier; J L Misset; P Morin; R Keiling; L Schwarzenberg; P Kerbrat; E Achille; J C Tronc
Journal:  Med Oncol Tumor Pharmacother       Date:  1984

6.  Prolonged inhibition of luteinizing hormone and testosterone levels in male rats with the luteinizing hormone-releasing hormone antagonist SB-75.

Authors:  L Bokser; S Bajusz; K Groot; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

7.  Tumor growth inhibition in patients with prostatic carcinoma treated with luteinizing hormone-releasing hormone agonists.

Authors:  G Tolis; D Ackman; A Stellos; A Mehta; F Labrie; A T Fazekas; A M Comaru-Schally; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

8.  Long-acting delivery systems for peptides: inhibition of rat prostate tumors by controlled release of [D-Trp6]luteinizing hormone-releasing hormone from injectable microcapsules.

Authors:  T W Redding; A V Schally; T R Tice; W E Meyers
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

9.  Inhibition of the growth of some hormone dependent tumors by D-Trp6-LH-RH.

Authors:  A V Schally; T W Redding; A M Comaru-Schally
Journal:  Med Oncol Tumor Pharmacother       Date:  1984

10.  D-Tryptophan-6 analog of luteinizing hormone-releasing hormone as a protective agent against testicular damage caused by cyclophosphamide in baboons.

Authors:  R W Lewis; K J Dowling; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205
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