Literature DB >> 6108141

The effect of baclofen on the cardiovascular system of the rat.

L A Chahl, S B Walker.   

Abstract

1 The cardiovascular responses to baclofen were investigated in anaesthetized rats. 2 Low doses of baclofen (less than 5 X 10(-8) mol), given intravenously, produced a transient fall in blood pressure and heart rate. Higher doses (greater than 5 X 10(-7) mol) produced a marked and prolonged increase in blood pressure accompanied by a rise in heart rate and cutaneous arterial dilatation. 3 The pressor and heart rate responses exhibited tachyphylaxis, and were abolished by hexamethonium, cervical cord section, reserpine-treatment and by a combination of alpha- and beta-adrenoceptor antagonists. 4 It is concluded that the increases in blood pressure and heart rate produced by high doses of baclofen are of central sympathetic origin.

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Year:  1980        PMID： 6108141      PMCID： PMC2044298          DOI： 10.1111/j.1476-5381.1980.tb07914.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Antagonism between Lioresal and substance P in rat spinal cord.

Authors:  K Saito; S Konishi; M Otsuka
Journal:  Brain Res       Date:  1975-10-24       Impact factor: 3.252

2.  The biological activity of d- and l-baclofen (Lioresal).

Authors:  H R Olpe; H Demiéville; V Baltzer; W L Bencze; W P Koella; P Wolf; H L Haas
Journal:  Eur J Pharmacol       Date:  1978-11-01       Impact factor: 4.432

3.  Effects of baclofen on dopamine metabolism and interaction with neuroleptic effects.

Authors:  P C Waldmeier; L Maitre
Journal:  Eur J Pharmacol       Date:  1978-01-15       Impact factor: 4.432

4.  Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat.

Authors:  D R Curtis; A W Duggan; D Felix; G A Johnston
Journal:  Brain Res       Date:  1971-09-10       Impact factor: 3.252

5.  Cardiovascular effects of baclofen in the rat.

Authors:  B Persson; M Henning
Journal:  J Pharm Pharmacol       Date:  1979-11       Impact factor: 3.765

6.  Effects of an antispastic drug (beta-(4-chlorophenyl)-gamma-aminobutyric acid) on Renshaw cell activity.

Authors:  R Benecke; J Meyer-Lohmann
Journal:  Neuropharmacology       Date:  1974-11       Impact factor: 5.250

7.  The effects of prostaglandins E1, E2 and F2alpha on the cutaneous vasculature of the rat.

Authors:  L A Chahl; R J Ladd
Journal:  Br J Pharmacol       Date:  1976-03       Impact factor: 8.739

8.  Is Lioresal (Baclofen) an antagonist of substance P?

Authors:  K J Fotherby; N J Morrish; R W Ryall
Journal:  Brain Res       Date:  1976-08-20       Impact factor: 3.252

9.  Effects of baclofen and gamma-hydroxybutyrate on rat striatal and mesolimbic 5-HT metabolism.

Authors:  P C Waldmeier; B Fehr
Journal:  Eur J Pharmacol       Date:  1978-05-15       Impact factor: 4.432

10.  Tolerance to the effects of baclofen and gamma-butyrolactone on locomotor activity and dopaminergic neurons in the mouse.

Authors:  G Gianutsos; K E Moore
Journal:  J Pharmacol Exp Ther       Date:  1978-12       Impact factor: 4.030
  10 in total
  7 in total

1.  The effects of baclofen on spinal and supraspinal micturition reflexes in rats.

Authors:  C A Maggi; P Santicioli; S Giuliani; M Furio; B Conte; P Meli; L Gragnani; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-08       Impact factor: 3.000

2.  GABAB receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat.

Authors:  A Kohlenbach; E Schlicker
Journal:  Br J Pharmacol       Date:  1990-06       Impact factor: 8.739

3.  Quantitative pharmacokinetic-pharmacodynamic modelling of baclofen-mediated cardiovascular effects using BP and heart rate in rats.

Authors:  Harriet Kamendi; Herbert Barthlow; David Lengel; Marie-Eve Beaudoin; Debra Snow; Jerome T Mettetal; Russell A Bialecki
Journal:  Br J Pharmacol       Date:  2016-08-25       Impact factor: 8.739

4.  Bicuculline insensitive effects of baclofen.

Authors:  L K Rägo; A M Zarkovsky
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-03       Impact factor: 3.000

Review 5.  gamma-Aminobutyric acid and cardiovascular function.

Authors:  F V DeFeudis
Journal:  Experientia       Date:  1983-08-15

6.  An integrative pharmacological approach to radio telemetry and blood sampling in pharmaceutical drug discovery and safety assessment.

Authors:  Dennis C Litwin; David J Lengel; Harriet W Kamendi; Russell A Bialecki
Journal:  Biomed Eng Online       Date:  2011-01-18       Impact factor: 2.819

7.  Biobehavioral effects of baclofen in anxious alcohol-dependent individuals: a randomized, double-blind, placebo-controlled, laboratory study.

Authors:  M Farokhnia; M L Schwandt; M R Lee; J W Bollinger; L A Farinelli; J P Amodio; L Sewell; T A Lionetti; D E Spero; L Leggio
Journal:  Transl Psychiatry       Date:  2017-04-25       Impact factor: 6.222
  7 in total

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