Literature DB >> 6107909

Activation of brain tryptophan hydroxylase by ATP-MG2+: dependence on calmodulin.

D M Kuhn, J P O'Callaghan, J Juskevich, W Lovenberg.   

Abstract

Tryptophan hydroxylase [tryptophan 5-monooxygenase, L-tryptophan,tetrahydropterin:oxygen oxidoreductase (5-hydroxylating), EC 1.14.16.4] is activated by phosphorylating conditions (ATP-Mg2+) in a calcium-dependent, cyclic AMP-independent manner. Addition to the phosphorylation reaction of certain antipsychotic drugs that bind to calmodulin, the heat-stable calcium-binding protein, prevents the activation of tryptophan hydroxylase by ATP-Mg2+ in a concentration-dependent fashion. External addition of purified calmodulin protects the enzyme from the drug-induced effects. Calmodulin-free tryptophan hydroxylase prepared by affinity chromatography on fluphenazine-Sepharose is not activated by ATP-Mg2+ whereas addition of calmodulin to calmodulin-free enzyme restores the responsiveness of the hydroxylase to ATP-MG2+ only in the presence of Ca2+. These results indicate that the activation of tryptophan hydroxylase by phosphorylating conditions is dependent on both calcium and calmodulin.

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Year:  1980        PMID： 6107909      PMCID： PMC349911          DOI： 10.1073/pnas.77.8.4688

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  High resolution two-dimensional electrophoresis of proteins.

Authors:  P H O'Farrell
Journal:  J Biol Chem       Date:  1975-05-25       Impact factor: 5.157

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  ATP, cyclic AMP, and magnesium increase the affinity of rat striatal tyrosine hydroxylase for its cofactor.

Authors:  W Lovenberg; E A Bruckwick; I Hanbauer
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

4.  Effects of phenothiazine tranquilizers on the cyclic 3',5'-adenosine monophosphate system of rat brain.

Authors:  P Uzunov; B Weiss
Journal:  Neuropharmacology       Date:  1971-11       Impact factor: 5.250

5.  Cyclic 3',5'-nucleotide phosphodiesterase. Evidence for and properties of a protein activator.

Authors:  W Y Cheung
Journal:  J Biol Chem       Date:  1971-05-10       Impact factor: 5.157

6.  Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain.

Authors:  P A Friedman; A H Kappelman; S Kaufman
Journal:  J Biol Chem       Date:  1972-07-10       Impact factor: 5.157

7.  Effect of intraventricular injection of 5,7-dihydroxytryptamine on regional tryptophan hydroxylase of rat brain.

Authors:  H G Baumgarten; S J Victor; W Lovenberg
Journal:  J Neurochem       Date:  1973-07       Impact factor: 5.372

8.  Solubilization and partial purification of tyrosine hydroxylase from bovine adrenal medulla.

Authors:  R Shiman; M Akino; S Kaufman
Journal:  J Biol Chem       Date:  1971-03-10       Impact factor: 5.157

9.  Psychopharmacological agents and the cyclic AMP system of rat brain.

Authors:  P Uzunov; B Weiss
Journal:  Adv Cyclic Nucleotide Res       Date:  1972

10.  Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin.

Authors:  E Jéquier; W Lovenberg; A Sjoerdsma
Journal:  Mol Pharmacol       Date:  1967-05       Impact factor: 4.436
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  11 in total

Review 1.  Regulatory properties of brain glutamate decarboxylase.

Authors:  D L Martin
Journal:  Cell Mol Neurobiol       Date:  1987-09       Impact factor: 5.046

Review 2.  Structure and function of the aromatic amino acid hydroxylases.

Authors:  S E Hufton; I G Jennings; R G Cotton
Journal:  Biochem J       Date:  1995-10-15       Impact factor: 3.857

3.  Mechanism of action of choleragen and E. coli heat-labile enterotoxin: activation of adenylate cyclase by ADP-ribosylation.

Authors:  J Moss; M Vaughan
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4.  Soluble protein kinase fractions from DEAE-cellulose chromatography. A comparison between brain and heart from the rat.

Authors:  R F Alderson; P Y Sze; M Costa
Journal:  Mol Cell Biochem       Date:  1982-12-10       Impact factor: 3.396

Review 5.  Calmodulin.

Authors:  Y M Lin
Journal:  Mol Cell Biochem       Date:  1982-06-11       Impact factor: 3.396

6.  Single-prolonged stress induce changes of CaM/CaMKIIα in the rats of dorsal raphe nucleus.

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Journal:  Neurochem Res       Date:  2012-05       Impact factor: 3.996

7.  The association between modified Nordic diet with sleep quality and circadian rhythm in overweight and obese woman: a cross-sectional study.

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Journal:  Eat Weight Disord       Date:  2021-11-10       Impact factor: 4.652

8.  Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.

Authors:  C Riganti; S Doublier; D Viarisio; E Miraglia; G Pescarmona; D Ghigo; A Bosia
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9.  Calcium-dependent interaction of S100b, troponin C, and calmodulin with an immobilized phenothiazine.

Authors:  D R Marshak; D M Watterson; L J Van Eldik
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

10.  Calcium-regulated phosphorylation in synaptosomal cytosol: dependence on calmodulin.

Authors:  J P O'Callaghan; L A Dunn; W Lovenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205
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