Literature DB >> 6105486

Pancreatic islet-cell damage in children with fatal viral infections.

A B Jenson, H S Rosenberg, A L Notkins.   

Abstract

The pancreases from 250 children with fatal infections caused by at least fourteen different viruses were examined for lesions in the islets of Langerhans. Viral cytopathology was found in 4 of 7 cases of Coxsackievirus B infection, 20 of 45 cases of cytomegalovirus infection, 2 of 14 cases of varicella-zoster infection, and 2 of 45 cases of congenital rubella. Destruction of beta cells and acute and chronic inflammatory infiltrates were found in islets from cases with Coxsackievirus B infections. Characteristic inclusion bodies were observed in islets from cases with cytomegalovirus and varicella-zoster infections. This survey provides further evidence that some viruses can infect and damage human beta cells.

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Year:  1980        PMID： 6105486

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  41 in total

1.  Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase.

Authors:  H S Hiemstra; N C Schloot; P A van Veelen; S J Willemen; K L Franken; J J van Rood; R R de Vries; A Chaudhuri; P O Behan; J W Drijfhout; B O Roep
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-27       Impact factor: 11.205

Review 2.  Prospects for the prevention and reversal of type 1 diabetes mellitus.

Authors:  Nikolai Petrovsky; Diego Silva; Desmond A Schatz
Journal:  Drugs       Date:  2002       Impact factor: 9.546

Review 3.  Genetic analysis of susceptibility to type 1 diabetes.

Authors:  J A Todd
Journal:  Springer Semin Immunopathol       Date:  1992

4.  Virus-induced diabetes in a transgenic model: role of cross-reacting viruses and quantitation of effector T cells needed to cause disease.

Authors:  N Sevilla; D Homann; M von Herrath; F Rodriguez; S Harkins; J L Whitton; M B Oldstone
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

5.  Prevention of reovirus type 2-induced diabetes-like syndrome in DBA/1 suckling mice by treatment with antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1.

Authors:  T Hayashi; S Yamamoto; T Onodera
Journal:  Int J Exp Pathol       Date:  1995-12       Impact factor: 1.925

Review 6.  Environmental factors in the development of Type 1 diabetes.

Authors:  Hui Peng; William Hagopian
Journal:  Rev Endocr Metab Disord       Date:  2006-09       Impact factor: 6.514

7.  Congenital rubella: citation virus or viral cause of type 1 diabetes?

Authors:  E A M Gale
Journal:  Diabetologia       Date:  2008-09       Impact factor: 10.122

8.  Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study.

Authors:  Hanna Viskari; Sami Oikarinen; Sanna Hoppu; Tytti Vuorinen; Heini Huhtala; Jorma Toppari; Riitta Veijola; Jorma Ilonen; Mikael Knip; Heikki Hyöty
Journal:  Diabetologia       Date:  2017-09-02       Impact factor: 10.122

9.  Asymptomatic cytomegalovirus infection is associated with increased risk of new-onset diabetes mellitus and impaired insulin release after renal transplantation.

Authors:  J Hjelmesaeth; S Sagedal; A Hartmann; H Rollag; T Egeland; M Hagen; K P Nordal; T Jenssen
Journal:  Diabetologia       Date:  2004-08-27       Impact factor: 10.122

Review 10.  Diabetes mellitus due to viruses--some recent developments.

Authors:  T M Szopa; P A Titchener; N D Portwood; K W Taylor
Journal:  Diabetologia       Date:  1993-08       Impact factor: 10.122
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