Hanna Viskari1,2, Sami Oikarinen3,4, Sanna Hoppu5, Tytti Vuorinen6,7, Heini Huhtala8, Jorma Toppari9,10, Riitta Veijola11, Jorma Ilonen12, Mikael Knip13,14,15,16, Heikki Hyöty3,4. 1. Department of Virology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. hanna.viskari@uta.fi. 2. Department of Internal Medicine, Tampere University Hospital, 33520, Tampere, Finland. hanna.viskari@uta.fi. 3. Department of Virology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 4. Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland. 5. Department of Intensive Care, Tampere University Hospital, Tampere, Finland. 6. Department of Clinical Virology, Turku University Hospital, Turku, Finland. 7. Department of Virology, University of Turku, Turku, Finland. 8. Faculty of Social Sciences, University of Tampere, Tampere, Finland. 9. Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland. 10. Department of Pediatrics, Turku University Hospital, Turku, Finland. 11. Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland. 12. Immunogenetics Laboratory, University of Turku and Turku University Hospital, Turku, Finland. 13. Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. 14. Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland. 15. Department of Pediatrics, Tampere University Hospital, Tampere, Finland. 16. Folklhälsan Research Center, Helsinki, Finland.
Abstract
AIMS/HYPOTHESIS: Animal and human studies have implied that enterovirus infections may modulate the risk of islet autoimmunity and type 1 diabetes. We set out to assess whether serial administration of live oral poliovirus vaccine (OPV) in early life can influence the initiation of islet autoimmunity in a cohort of genetically predisposed children. METHODS: OPV was administered to 64 children and a further 251 children received inactivated poliovirus vaccine (IPV). The emergence of type 1 diabetes-associated autoantibodies in serum (autoantibodies to GAD, insulinoma-associated protein 2, insulin and islet cells) was monitored during prospective follow-up. Stool and serum samples were collected for enterovirus detection by RT-PCR. RESULTS: Administration of OPV increased enterovirus detected in stool samples from 11.3% to 38.9% (p < 0.001) during the first year of life. During the follow-up (median 11.0 years), at least one autoantibody was detected in 17.2% of children vaccinated with OPV and 19.1% with IPV (p = 0.723). At least two autoantibodies were observed in 3.1% and 6.8% of children, respectively (p = 0.384). CONCLUSIONS/ INTERPRETATION: Replication of attenuated poliovirus strains in gut mucosa is not associated with an increased risk of islet autoimmunity. TRIAL REGISTRATION: ClinicalTrials.gov : NCT02961595.
AIMS/HYPOTHESIS: Animal and human studies have implied that enterovirus infections may modulate the risk of islet autoimmunity and type 1 diabetes. We set out to assess whether serial administration of live oral poliovirus vaccine (OPV) in early life can influence the initiation of islet autoimmunity in a cohort of genetically predisposed children. METHODS: OPV was administered to 64 children and a further 251 children received inactivated poliovirus vaccine (IPV). The emergence of type 1 diabetes-associated autoantibodies in serum (autoantibodies to GAD, insulinoma-associated protein 2, insulin and islet cells) was monitored during prospective follow-up. Stool and serum samples were collected for enterovirus detection by RT-PCR. RESULTS: Administration of OPV increased enterovirus detected in stool samples from 11.3% to 38.9% (p < 0.001) during the first year of life. During the follow-up (median 11.0 years), at least one autoantibody was detected in 17.2% of children vaccinated with OPV and 19.1% with IPV (p = 0.723). At least two autoantibodies were observed in 3.1% and 6.8% of children, respectively (p = 0.384). CONCLUSIONS/ INTERPRETATION: Replication of attenuated poliovirus strains in gut mucosa is not associated with an increased risk of islet autoimmunity. TRIAL REGISTRATION: ClinicalTrials.gov : NCT02961595.
Authors: V Parikka; K Näntö-Salonen; M Saarinen; T Simell; J Ilonen; H Hyöty; R Veijola; M Knip; O Simell Journal: Diabetologia Date: 2012-03-23 Impact factor: 10.122
Authors: Hanna Honkanen; Sami Oikarinen; Noora Nurminen; Olli H Laitinen; Heini Huhtala; Jussi Lehtonen; Tanja Ruokoranta; Minna M Hankaniemi; Valérie Lecouturier; Jeffrey W Almond; Sisko Tauriainen; Olli Simell; Jorma Ilonen; Riitta Veijola; Hanna Viskari; Mikael Knip; Heikki Hyöty Journal: Diabetologia Date: 2017-01-09 Impact factor: 10.122
Authors: Sami Oikarinen; Sisko Tauriainen; Hanna Viskari; Olli Simell; Mikael Knip; Suvi Virtanen; Heikki Hyöty Journal: J Clin Virol Date: 2009-02-03 Impact factor: 3.168
Authors: Christian R Kahrs; Katerina Chuda; German Tapia; Lars C Stene; Karl Mårild; Trond Rasmussen; Kjersti S Rønningen; Knut E A Lundin; Lenka Kramna; Ondrej Cinek; Ketil Størdal Journal: BMJ Date: 2019-02-13