Literature DB >> 6103735

Alteration of tyrosine hydroxylase activity in the locus coeruleus after administration of p-chlorophenylalanine.

F Crespi, M Buda, A McRae-Degueurce, J F Pujol.   

Abstract

The time course of the variations in tyrosine hydroxylase activity (THA) and serotonin (5-HT) content were measured in the rat locus coeruleus after parachlorophenylalanine (PCPA) administration. Highly significant decreases in the 5-HT content in LC were found 24-48 h after PCPA treatment (300 mg/kg daily). An increase in THA (in the LC) was found to be significant 4 days after 2 successive injections of PCPA and after 4 successive injections of the drug THA gradually increased, reaching a maximum around 4 days after the last injection. This maximum increase in THA was greatly reduced when 5-HTP was simultaneously administered with PCPA. These results join others which suggest that a serotonin-mediated mechanism could be one of the processes controlling noradrenaline metabolism in the locus coeruleus.

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Year:  1980        PMID： 6103735     DOI： 10.1016/0006-8993(80)91298-6

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

1.  Evidence for a possible interaction between noradrenergic and serotonergic neurotransmission in the retrieval of a previously learned aversive habit in mice.

Authors:  H J Normile; H J Altman
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

2.  Ethanol induced antidepressant-like effect in the mouse forced swimming test: modulation by serotonergic system.

Authors:  Nishant S Jain; Uday Kannamwar; Lokesh Verma
Journal:  Psychopharmacology (Berl)       Date:  2016-11-12       Impact factor: 4.530

Review 3.  Serotonin, memory, and the aging brain.

Authors:  W J McEntee; T H Crook
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

4.  Serotonergic mechanisms on breathing modulation in the rat locus coeruleus.

Authors:  Vanessa de Souza Moreno; Kênia C Bícego; Raphael E Szawka; Janete A Anselmo-Franci; Luciane H Gargaglioni
Journal:  Pflugers Arch       Date:  2009-10-21       Impact factor: 3.657

5.  Serotonin-norepinephrine interactions: a voltammetric study on the effect of serotonin receptor stimulation followed in the N. raphe dorsalis and the Locus coeruleus of the rat.

Authors:  H W Clement; D Gemsa; W Wesemann
Journal:  J Neural Transm Gen Sect       Date:  1992

6.  Evidence that 5-HT2 receptor activation decreases noradrenaline release in rat hippocampus in vivo.

Authors:  C J Done; T Sharp
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

Review 7.  Tyrosine hydroxylase regulation in the central nervous system.

Authors:  J M Masserano; N Weiner
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

8.  Increase of noradrenaline release in the hypothalamus of freely moving rat by postsynaptic 5-hydroxytryptamine1A receptor activation.

Authors:  M Suzuki; T Matsuda; S Asano; P Somboonthum; K Takuma; A Baba
Journal:  Br J Pharmacol       Date:  1995-06       Impact factor: 8.739

9.  Ethanol, monoamines, and affect.

Authors:  C J Clayton; R E Hicks
Journal:  J Neural Transm Gen Sect       Date:  1994
  9 in total

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