Literature DB >> 6103639

Sulphonylurea (glubenclamide) enhances somatostatin and inhibits glucagon release induced by arginine.

S Efendić, F Enzmann, A Nylén, K Uvnäs-Wallensten, R Luft.   

Abstract

Arginine significantly stimulated the release of insulin, glucagon and somatostatin from the isolated perfused rat pancreas. A sulphonylurea, glibenclamide, markedly enhanced the effect of arginine on somatostatin release and inhibited its effect on glucagon release. Insulin release was not modulated by addition of glibenclamide. These findings support the idea of a paracrine interaction of islets hormones.

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Year:  1980        PMID： 6103639     DOI： 10.1111/j.1748-1716.1980.tb06527.x

Source DB:  PubMed          Journal:  Acta Physiol Scand        ISSN： 0001-6772


  9 in total

Review 1.  Molecular defects in insulin secretion in type-2 diabetes.

Authors:  Frances M Ashcroft; Patrik Rorsman
Journal:  Rev Endocr Metab Disord       Date:  2004-05       Impact factor: 6.514

2.  Diminished glucagon suppression after β-cell reduction is due to impaired α-cell function rather than an expansion of α-cell mass.

Authors:  Juris J Meier; Sandra Ueberberg; Simone Korbas; Stephan Schneider
Journal:  Am J Physiol Endocrinol Metab       Date:  2011-02-01       Impact factor: 4.310

Review 3.  Secretion of somatostatin from the normal and diabetic pancreas. Studies in vitro.

Authors:  K Hermansen
Journal:  Diabetologia       Date:  1980       Impact factor: 10.122

4.  Plasma concentrations of gastrin and somatostatin after breast feeding in 4 day old infants.

Authors:  G Marchini; J Winberg; K Uvnäs-Moberg
Journal:  Arch Dis Child       Date:  1988-10       Impact factor: 3.791

5.  Quantitative relationships between suckling-induced teat stimulation and the release of prolactin, gastrin, somatostatin, insulin, glucagon and vasoactive intestinal polypeptide in sows.

Authors:  B Algers; A Madej; S Rojanasthien; K Uvnäs-Moberg
Journal:  Vet Res Commun       Date:  1991       Impact factor: 2.459

6.  Sulfonylurea-induced inhibition of glucagon secretion from the perfused rat pancreas: evidence for a direct, non-paracrine effect.

Authors:  C G Ostenson; A Nylén; V Grill; M Gutniak; S Efendić
Journal:  Diabetologia       Date:  1986-12       Impact factor: 10.122

7.  Effect of a new hypoglycaemic agent (HB 699) on the in vivo secretion of pancreatic hormones in the dog.

Authors:  G Ribes; E R Trimble; J P Blayac; C B Wollheim; R Puech; M M Loubatières-Mariani
Journal:  Diabetologia       Date:  1981-04       Impact factor: 10.122

8.  Effect of a non-sulphonylurea hypoglycaemic agent, KAD-1229 on hormone secretion in the isolated perfused pancreas of the rat.

Authors:  M Kinukawa; H Ohnota; Y Ajisawa
Journal:  Br J Pharmacol       Date:  1996-04       Impact factor: 8.739

9.  Dissociation of oxytocin effects on body weight in two variants of female Sprague-Dawley rats.

Authors:  K Uvnäs-Moberg; P Alster; M Petersson
Journal:  Integr Physiol Behav Sci       Date:  1996 Jan-Mar
  9 in total

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