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Literature DB >> 6102487

Ketotifen in adult asthma.

Abstract

The efficacy and adverse effects of ketotifen 1 mg twice daily and 2 mg twice daily were compared with placebo in 50 patients with atopic asthma in a multicentre, double-blind study. Ketotifen in the higher dosage caused a slight reduction in salbutamol usage and a modest improvement in breathing in patients not already receiving inhaled corticosteroids. The drug was ineffective in patients receiving inhaled corticosteroids. Drowsiness was a troublesome effect causing withdrawal from treatment or reduction of dosage in seven patients while receiving ketotifen compared with only three while receiving placebo.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1980 PMID： 6102487 PMCID： PMC1600936 DOI： 10.1136/bmj.280.6211.360

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

6 in total

1. Comparison between ketotifen and DSCG in bronchial challenge.

Authors: R Pauwels; H Lamont; M Van Der Straeten
Journal: Clin Allergy Date: 1978-05

2. The pharmacological properties of a new, orally active antianaphylactic compound: ketotifen, a benzocycloheptathiophene.

Authors: U Martin; D Römer
Journal: Arzneimittelforschung Date: 1978

3. A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma.

Authors: J B Howell; R E Altounyan
Journal: Lancet Date: 1967-09-09 Impact factor: 79.321

4. Disodium chromoglycate in the treatment of allergic bronchial asthma.

Authors: F Moran; J D Bankier; G Boyd
Journal: Lancet Date: 1968-07-20 Impact factor: 79.321

5. Clinical investigation of agents with prophylactic anti-allergic effects in bronchial asthma.

Authors: L Craps; C Greenwood; P Radielovic
Journal: Clin Allergy Date: 1978-07

6. A placebo-controlled trial of ketotifen (HC 20-511, Sandoz) in allergen induced asthma and comparison with disodium cromoglycate.

Authors: A Wells; B Taylor
Journal: Clin Allergy Date: 1979-05

6 in total

11 in total

Review 1. New drugs in respiratory disorders: I.

Authors: D C Flenley
Journal: Br Med J (Clin Res Ed) Date: 1983-03-12

2. Effect of prednisolone and ketotifen on beta 2-adrenoceptors in asthmatic patients receiving beta 2-bronchodilators.

Authors: O E Brodde; U Howe; S Egerszegi; N Konietzko; M C Michel
Journal: Eur J Clin Pharmacol Date: 1988 Impact factor: 2.953

3. Ketotifen and asthma.

Authors: J K Sarsfield
Journal: Arch Dis Child Date: 1981-04 Impact factor: 3.791

4. Drugs for asthma: mast-cell stabilisers.

Authors:
Journal: Br Med J (Clin Res Ed) Date: 1981-03-28

5. Drugs for asthma: mast-cell stabilisers.

Authors:
Journal: Br Med J (Clin Res Ed) Date: 1981-02-21

6. A trial of ketotifen in intrinsic asthma.

Authors: M I Ullah; J Brostoff; K B Saunders
Journal: Br J Clin Pharmacol Date: 1981-09 Impact factor: 4.335

7. Ketotifen in atopic asthma and exercise-induced asthma.

Authors: I S Petheram; J Moxham; C W Bierman; M McAllen; S G Spiro
Journal: Thorax Date: 1981-04 Impact factor: 9.139

8. Evaluation of ketotifen (HC20-511) in bronchial asthma.

Authors: J W Paterson; R H Yellin; R A Tarala
Journal: Eur J Clin Pharmacol Date: 1983 Impact factor: 2.953

9. Comparative clinical evaluation of ketotifen and montelukast sodium in asthmatic Iraqi patients.

Authors: Fadyia Y Al-Hamdani
Journal: Saudi Pharm J Date: 2010-07-29 Impact factor: 4.330

10. Ketotifen and nocturnal asthma.

Authors: J R Catterall; P M Calverley; J T Power; C M Shapiro; N J Douglas; D C Flenley
Journal: Thorax Date: 1983-11 Impact factor: 9.139