Literature DB >> 6100431

Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica.

F D Gillin, D S Reiner, M Suffness.   

Abstract

Bruceantin, purified from an Ethiopian plant used to treat dysentery, killed Entamoeba histolytica in vitro (IC50 [the concentration of drug which decreased the number of colonies to half that of controls] = 0.018 microgram/ml). Six related quassinoids of 17 tested were also amoebicidal. No relationship between quassinoid structure and amoebicidal activity was apparent.

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Year:  1982        PMID： 6100431      PMCID： PMC183739          DOI： 10.1128/AAC.22.2.342

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  The use of glaucarubin (a crystalline glycoside isolated from Simarouba glauca) in the treatment of human colonic amebiasis.

Authors:  F VAN ASSENDELFT; J W MILLER; D T MINTZ; J A SCHACK; P OTTOLENGHI; H MOST
Journal:  Am J Trop Med Hyg       Date:  1956-05       Impact factor: 2.345

2.  Clinical trial of glaucarubin in treatment of amebiasis.

Authors:  E C DEL POZO; M ALCARAZ
Journal:  Am J Med       Date:  1956-03       Impact factor: 4.965

3.  Action of antibiotics against intestinal amoebae in vitro.

Authors:  W BALAMUTH
Journal:  Ann N Y Acad Sci       Date:  1952-12-30       Impact factor: 5.691

4.  Mode of action of the antitumor compound bruceantin, an inhibitor of protein synthesis.

Authors:  L L Liao; S M Kupchan; S B Horwitz
Journal:  Mol Pharmacol       Date:  1976-01       Impact factor: 4.436

5.  Clonal growth of Entamoeba histolytica and other species of Entamoeba in agar.

Authors:  F D Gillin; L S Diamond
Journal:  J Protozool       Date:  1978-11

6.  A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba.

Authors:  L S Diamond; D R Harlow; C C Cunnick
Journal:  Trans R Soc Trop Med Hyg       Date:  1978       Impact factor: 2.184

Review 7.  Quassinoid Bitter Principles.

Authors:  J Polonsky
Journal:  Fortschr Chem Org Naturst       Date:  1973

8.  Inhibition of clonal growth of Giardia lamblia and Entamoeba histolytica by metronidazole, quinacrine, and other antimicrobial agents.

Authors:  F D Gillin; L S Diamond
Journal:  J Antimicrob Chemother       Date:  1981-10       Impact factor: 5.790

9.  Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro.

Authors:  W Trager; J Polonsky
Journal:  Am J Trop Med Hyg       Date:  1981-05       Impact factor: 2.345
  9 in total
  7 in total

1.  Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids.

Authors:  C W Wright; M J O'Neill; J D Phillipson; D C Warhurst
Journal:  Antimicrob Agents Chemother       Date:  1988-11       Impact factor: 5.191

2.  Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids.

Authors:  M J O'Neill; D H Bray; P Boardman; J D Phillipson; D C Warhurst; W Peters; M Suffness
Journal:  Antimicrob Agents Chemother       Date:  1986-07       Impact factor: 5.191

3.  Antifeedant activity of quassinoids.

Authors:  V Leskinen; J Polonsky; S Bhatnagar
Journal:  J Chem Ecol       Date:  1984-10       Impact factor: 2.626

4.  Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection.

Authors:  M Chen; T G Theander; S B Christensen; L Hviid; L Zhai; A Kharazmi
Journal:  Antimicrob Agents Chemother       Date:  1994-07       Impact factor: 5.191

5.  Evaluation of in-vivo antidiarrhoeal and in-vitro antibacterial activities of the root extract of Brucea antidysenterica J. F. Mill (Simaroubaceae).

Authors:  Kaleab Alemayehu Zewdie; Dayananda Bhoumik; Dawit Zewdu Wondafrash; Kald Beshir Tuem
Journal:  BMC Complement Med Ther       Date:  2020-06-30

6.  Antimalarial Activity of Hydromethanolic Crude Extract and Chloroform Fraction of Brucea antidysenterica Leaves in Plasmodium berghei-Infected Mice.

Authors:  Tezera Jemere Aragaw; Kefyalew Ayalew Getahun
Journal:  Evid Based Complement Alternat Med       Date:  2021-10-13       Impact factor: 2.629

7.  Toxicological study of the butanol fractionated root extract of Asparagus africanus Lam., on some blood parameter and histopathology of liver and kidney in mice.

Authors:  Sintayehu Kebede; Mekbeb Afework; Asfaw Debella; Wondwossen Ergete; Eyasu Makonnen
Journal:  BMC Res Notes       Date:  2016-01-27
  7 in total

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