Literature DB >> 6098353

Receptors for multiplication-stimulating activity (MSA) on rabbit chondrocytes.

I K Ashton, J H Soul.   

Abstract

Multiplication-stimulating activity (125I-MSA) has been shown to bind to isolated rabbit chondrocytes, the binding being dependent on time, temperature, and cell density. Nonspecific binding was approximately 15%. Unlabelled MSA at 100 ng/ml inhibited 125I-MSA binding by 50%. Porcine insulin (0.5-10 micrograms/ml) did not compete with MSA but resulted in a 10-15% increase in 125I-MSA binding. The data suggest that normal chondrocytes carry IGF2-type receptors as well as the IGF1 type previously described.

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Year:  1984        PMID： 6098353     DOI： 10.1007/bf02405369

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  18 in total

1.  DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors:  B J DAVIS
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

2.  An assay for plasma somatomedin: [3H]thymidine incorporation by isolated rabbit chondrocytes.

Authors:  I K Ashton; M J Francis
Journal:  J Endocrinol       Date:  1977-08       Impact factor: 4.286

3.  The iodination of follicle-stimulating and other hormones for radioimmunoassay.

Authors:  W R Butt
Journal:  J Endocrinol       Date:  1972-11       Impact factor: 4.286

4.  Purified multiplication-stimulating activity from rat liver cell conditioned medium: comparison of biological activities with calf serum, insulin, and somatomedin.

Authors:  G L Smith; H M Temin
Journal:  J Cell Physiol       Date:  1974-10       Impact factor: 6.384

5.  Demonstration of receptors for insulin and insulin-like growth factors on Swarm rat chondrosarcoma chondrocytes. Evidence that insulin stimulates proteoglycan synthesis through the insulin receptor.

Authors:  T P Foley; S P Nissley; R L Stevens; G L King; V C Hascall; R E Humbel; P A Short; M M Rechler
Journal:  J Biol Chem       Date:  1982-01-25       Impact factor: 5.157

6.  Affinity labeling of multiplication stimulating activity receptors in membranes from rat and human tissues.

Authors:  J Massague; B J Guillette; M P Czech
Journal:  J Biol Chem       Date:  1981-03-10       Impact factor: 5.157

7.  Synthesis of multiplication-stimulating activity (rat insulin-like growth factor II) by rat embryo fibroblasts.

Authors:  S O Adams; S P Nissley; L A Greenstein; Y W Yang; M M Rechler
Journal:  Endocrinology       Date:  1983-03       Impact factor: 4.736

8.  Action of multiplication-stimulating activity on [3H]thymidine incorporation in rabbit and human fetal chondrocytes in vitro.

Authors:  I K Ashton; A E Pocock
Journal:  J Endocrinol       Date:  1983-10       Impact factor: 4.286

9.  Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

Authors:  H Marquardt; G J Todaro; L E Henderson; S Oroszlan
Journal:  J Biol Chem       Date:  1981-07-10       Impact factor: 5.157

10.  Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor.

Authors:  G L King; C R Kahn; M M Rechler; S P Nissley
Journal:  J Clin Invest       Date:  1980-07       Impact factor: 14.808
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