Literature DB >> 6097454

Cimetidine and ranitidine: their interaction with human and pig liver microsomes and with purified cytochrome P-450.

S Rendić, H H Ruf, P Weber, F Kajfez.   

Abstract

Cimetidine and ranitidine interact with microsomes from human and pig liver and with purified cytochrome P-450 in the ligand-type manner. The affinity for cimetidine is about 10 times as high as that for ranitidine. Accordingly amplitudes of the specta are much higher for cimetidine. These results are in accordance with those obtained earlier with rat liver microsomes. The inhibitory potency of either compound with regard to dealkylation of 7-ethoxycoumarin appears to be less in the human preparation.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6097454     DOI： 10.1007/BF03189641

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  14 in total

1.  Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine.

Authors:  G J Durant; J C Emmett; C R Ganellin; P D Miles; M E Parsons; H D Prain; G R White
Journal:  J Med Chem       Date:  1977-07       Impact factor: 7.446

2.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

3.  Determination of serum proteins by means of the biuret reaction.

Authors:  A G GORNALL; C J BARDAWILL; M M DAVID
Journal:  J Biol Chem       Date:  1949-02       Impact factor: 5.157

4.  Hydroxylation of aliphatic compounds by liver microsomes. I. The distribution pattern of isomeric alcohols.

Authors:  U Frommer; V Ullrich; H Staudinger
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1970-08

Review 5.  Drug interactions with cimetidine.

Authors:  A Somogyi; R Gugler
Journal:  Clin Pharmacokinet       Date:  1982 Jan-Feb       Impact factor: 6.447

6.  Preparation and properties of partially purified cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase from rabbit liver microsomes.

Authors:  T A van der Hoeven; M J Coon
Journal:  J Biol Chem       Date:  1974-10-10       Impact factor: 5.157

7.  The effect of cimetidine on in vitro and in vivo microsomal drug metabolism in the rat.

Authors:  O Pelkonen; J Puurunen
Journal:  Biochem Pharmacol       Date:  1980-11-15       Impact factor: 5.858

Review 8.  Cimetidine as an inhibitor of drug metabolism: therapeutic implications and review of the literature.

Authors:  J H Bauman; B J Kimelblatt
Journal:  Drug Intell Clin Pharm       Date:  1982-05

Review 9.  Ranitidine: a review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases.

Authors:  R N Brogden; A A Carmine; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1982-10       Impact factor: 9.546

10.  Characterization of cimetidine, ranitidine, and related structures' interaction with cytochrome P-450.

Authors:  S Rendić; F Kajfez; H H Ruf
Journal:  Drug Metab Dispos       Date:  1983 Mar-Apr       Impact factor: 3.922
View more
  6 in total

1.  Cimetidine and ranitidine on basal and ACTH-stimulated steroidogenesis.

Authors:  R G Karlstadt; W O Frank; L A Antell; S W Shapowal; R H Palmer
Journal:  Gut       Date:  1987-12       Impact factor: 23.059

Review 2.  Side effects of ranitidine.

Authors:  T Vial; C Goubier; A Bergeret; F Cabrera; J C Evreux; J Descotes
Journal:  Drug Saf       Date:  1991 Mar-Apr       Impact factor: 5.606

3.  Study of the in vitro bioactivation of albendazole in human liver microsomes and hepatoma cell lines.

Authors:  S Rolin; H Souhaili-el Amri; A M Batt; M Levy; D Bagrel; G Siest
Journal:  Cell Biol Toxicol       Date:  1989-01       Impact factor: 6.691

Review 4.  Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases.

Authors:  S M Grant; H D Langtry; R N Brogden
Journal:  Drugs       Date:  1989-06       Impact factor: 9.546

5.  Interactions of the histamine H2-receptor antagonist etintidine with rat liver cytochrome P-450: a comparison with cimetidine.

Authors:  M Schulz; A Schmoldt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-10       Impact factor: 3.000

6.  Concurrent use of proton pump inhibitors or H2 blockers did not adversely affect nilotinib efficacy in patients with chronic myeloid leukemia.

Authors:  Ophelia Q P Yin; Frank J Giles; Michele Baccarani; Philipp le Coutre; Ovidiu Chiparus; Neil Gallagher; Giuseppe Saglio; Timothy P Hughes; Andreas Hochhaus; Hagop M Kantarjian; Richard A Larson
Journal:  Cancer Chemother Pharmacol       Date:  2012-05-24       Impact factor: 3.333
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.