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Literature DB >> 6097320

Saturation behavior of single, amiloride-sensitive Na+ channels in planar lipid bilayers.

Abstract

Single epithelial Na+ channels incorporated into planar lipid bilayers were studied to determine the effects of Na concentration on its own conductance. Amiloride-sensitive Na+ channels were obtained from apical membrane vesicles made from A6 cells, a continuous epithelial cell-line derived from amphibian kidney. Single-channel conductance was found to be a saturable function of Na+ concentration, with a Michaelis constant of approximately 17 or 47 mM, for a Gmax of approximately 4 or 44 pS, respectively.

Entities: Chemical

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Year: 1984 PMID： 6097320 PMCID： PMC1435104 DOI： 10.1016/S0006-3495(84)84082-5

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

11 in total

1. On the mechanism of active sodium transport across the frog skin.

Authors: L B KIRSCHNER
Journal: J Cell Comp Physiol Date: 1955-02

2. Effects of pH, Ca, ADH, and theophylline on kinetics of Na entry in frog skin.

Authors: L J Mandel
Journal: Am J Physiol Date: 1978-07

3. Current-voltage curve of sodium channels and concentration dependence of sodium permeability in frog skin.

Authors: W Fuchs; E H Larsen; B Lindemann
Journal: J Physiol Date: 1977-05 Impact factor: 5.182

4. Concentration dependence of currents through single sodium-selective pores in frog skin.

Authors: W Van Driessche; B Lindemann
Journal: Nature Date: 1979-11-29 Impact factor: 49.962

5. Reconstitution in planar lipid bilayers of a Ca2+-dependent K+ channel from transverse tubule membranes isolated from rabbit skeletal muscle.

Authors: R Latorre; C Vergara; C Hidalgo
Journal: Proc Natl Acad Sci U S A Date: 1982-02 Impact factor: 11.205

6. Aldosterone-stimulated sodium uptake by apical membrane vesicles from A6 cells.

Authors: S Sariban-Sohraby; M B Burg; R J Turner
Journal: J Biol Chem Date: 1984-09-25 Impact factor: 5.157

7. Amiloride-sensitive epithelial Na+ channels reconstituted into planar lipid bilayer membranes.

Authors: S Sariban-Sohraby; R Latorre; M Burg; L Olans; D Benos
Journal: Nature Date: 1984 Mar 1-7 Impact factor: 49.962

8. Sodium-specific membrane channels of frog skin are pores: current fluctuations reveal high turnover.

Authors: B Lindemann; W Van Driessche
Journal: Science Date: 1977-01-21 Impact factor: 47.728

9. Current-voltage analysis of apical sodium transport in toad urinary bladder: effects of inhibitors of transport and metabolism.

Authors: L G Palmer; I S Edelman; B Lindemann
Journal: J Membr Biol Date: 1980-11-15 Impact factor: 1.843

Review 10. Amiloride: a molecular probe of sodium transport in tissues and cells.

Authors: D J Benos
Journal: Am J Physiol Date: 1982-03

17 in total

1. Paracellular ion channel at the tight junction.

Authors: Vivian W Tang; Daniel A Goodenough
Journal: Biophys J Date: 2003-03 Impact factor: 4.033

2. Diversity of channels generated by different combinations of epithelial sodium channel subunits.

Authors: C M McNicholas; C M Canessa
Journal: J Gen Physiol Date: 1997-06 Impact factor: 4.086

3. Na+ transport and impedance properties of cultured renal (A6 and 2F3) epithelia.

Authors: N K Wills; R K Purcell; C Clausen
Journal: J Membr Biol Date: 1992-02 Impact factor: 1.843

Review 4. Ion selectivity of epithelial Na channels.

Authors: L G Palmer
Journal: J Membr Biol Date: 1987 Impact factor: 1.843

5. Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule.

Authors: L G Palmer; G Frindt
Journal: Proc Natl Acad Sci U S A Date: 1986-04 Impact factor: 11.205

6. Sodium-selective channels in membranes of rat macrophages.

Authors: Y A Negulyaev; E A Vedernikova
Journal: J Membr Biol Date: 1994-02 Impact factor: 1.843

Review 7. Regulation of renal epithelial sodium channels.

Authors: P Duchatelle; A Ohara; B N Ling; A E Kemendy; K E Kokko; P S Matsumoto; D C Eaton
Journal: Mol Cell Biochem Date: 1992-09-08 Impact factor: 3.396

8. Sodium-dependent regulation of epithelial sodium channel densities in frog skin; a role for the cytoskeleton.

Authors: W J Els; K Y Chou
Journal: J Physiol Date: 1993-03 Impact factor: 5.182

9. Cation permeability of a cloned rat epithelial amiloride-sensitive Na+ channel.

Authors: I I Ismailov; V G Shlyonsky; O Alvarez; D J Benos
Journal: J Physiol Date: 1997-10-15 Impact factor: 5.182

10. Voltage dependence of Na channel blockage by amiloride: relaxation effects in admittance spectra.

Authors: J Warncke; B Lindemann
Journal: J Membr Biol Date: 1985 Impact factor: 1.843