Literature DB >> 299785

Sodium-specific membrane channels of frog skin are pores: current fluctuations reveal high turnover.

B Lindemann, W Van Driessche.   

Abstract

The reversible sodium transport blocker amiloride causes current fluctuations at the apical membrane of the outer stratum granulosum of frog skin. Their power density spectra reveal that single transport sites translocate more than 10(6) sodium ions per second, which indicates a pore mechanism. The density of open plus amiloride-blocked pores is in the order of 10(8) pores per square centimeter of skin area with 60 millimolar sodium and 18 micromolar amiloride in the outer solution.

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Year:  1977        PMID： 299785     DOI： 10.1126/science.299785

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  100 in total

1.  Noise analysis and single-channel observations of 4 pS chloride channels in human airway epithelia.

Authors:  M Duszyk; A S French; S F Man
Journal:  Biophys J       Date:  1992-02       Impact factor: 4.033

2.  Capacitance, short-circuit current and osmotic water flow across different regions of the isolated toad skin.

Authors:  C A Baker; S D Hillyard
Journal:  J Comp Physiol B       Date:  1992       Impact factor: 2.200

Review 3.  Perspectives of taste reception.

Authors:  P Avenet; B Lindemann
Journal:  J Membr Biol       Date:  1989-11       Impact factor: 1.843

Review 4.  ENaC structure and function in the wake of a resolved structure of a family member.

Authors:  Ossama B Kashlan; Thomas R Kleyman
Journal:  Am J Physiol Renal Physiol       Date:  2011-07-13

5.  Interactions between impermeant blocking ions in the cystic fibrosis transmembrane conductance regulator chloride channel pore: evidence for anion-induced conformational changes.

Authors:  Ning Ge; Paul Linsdell
Journal:  J Membr Biol       Date:  2006-06-22       Impact factor: 1.843

6.  Development of aldosterone-stimulation of short-circuit current across larval frog skin.

Authors:  S D Hillyard; W Van Driessche
Journal:  J Comp Physiol B       Date:  1991       Impact factor: 2.200

7.  Estimation of the density of sodium entry sites in frog skin epithelium from the uptake of [3H]benzamil.

Authors:  J Aceves; A W Cuthbert; J M Edwardson
Journal:  J Physiol       Date:  1979-10       Impact factor: 5.182

8.  Uptake of [3H]benzamil at different sodium concentrations. Inferences regarding the regulation of sodium permeability.

Authors:  J Aceves; A W Cuthbert
Journal:  J Physiol       Date:  1979-10       Impact factor: 5.182

9.  Saturable K+ pathway across the outer border of frog skin (rana temporaria): kinetics and inhibition by Cs+ and other cations.

Authors:  W Zeiske; W Van Driessche
Journal:  J Membr Biol       Date:  1979-05-07       Impact factor: 1.843

10.  The sensitivity of apical Na+ permeability in frog skin to hypertonic stress.

Authors:  W Zeiske; W Van Driessche
Journal:  Pflugers Arch       Date:  1984-02       Impact factor: 3.657
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